The kinesin-13 MCAK has an unconventional ATPase cycle adapted for microtubule depolymerization.
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Review: Mechanochemistry of the kinesin-1 ATPaseCoupling of kinesin ATP turnover to translocation and microtubule regulation: one engine, many machinesS. pombe kinesins-8 promote both nucleation and catastrophe of microtubulesEvolving tip structures can explain age-dependent microtubule catastrophe.Aurora B inhibits MCAK activity through a phosphoconformational switch that reduces microtubule associationSpatiotemporal dynamics of Aurora B-PLK1-MCAK signaling axis orchestrates kinetochore bi-orientation and faithful chromosome segregation.Kinesin-5 is a microtubule polymerase.Kinesin Motor Enzymology: Chemistry, Structure, and Physics of Nanoscale Molecular MachinesInsight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin.The contribution of αβ-tubulin curvature to microtubule dynamics.Nucleotide exchange in dimeric MCAK induces longitudinal and lateral stress at microtubule ends to support depolymerization.Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target.Emergent Properties of the Metaphase Spindle.New Insights into the Coupling between Microtubule Depolymerization and ATP Hydrolysis by Kinesin-13 Protein Kif2C.Move in for the kill: motile microtubule regulators.Microtubule catastrophe and rescue.Molecular insight into the regulation and function of MCAK.Use of stopped-flow fluorescence and labeled nucleotides to analyze the ATP turnover cycle of kinesins.HX-MS2 for high performance conformational analysis of complex protein states.The family-specific α4-helix of the kinesin-13, MCAK, is critical to microtubule end recognition.Kif2C minimal functional domain has unusual nucleotide binding properties that are adapted to microtubule depolymerization.Interaction of a novel fluorescent GTP analogue with the small G-protein K-Ras.Synthesis and fluorescence characteristics of ATP-based FRET probes.A Tubulin Binding Switch Underlies Kip3/Kinesin-8 Depolymerase Activity.A Cdk1 phosphomimic mutant of MCAK impairs microtubule end recognition.Kinesin Processivity Is Determined by a Kinetic Race from a Vulnerable One-Head-Bound State.Altered chemomechanical coupling causes impaired motility of the kinesin-4 motors KIF27 and KIF7.Nonequilibrium Diffusion and Capture Mechanism Ensures Tip Localization of Regulating Proteins on Dynamic Filaments.Cryo-EM reveals the structural basis of microtubule depolymerization by kinesin-13s.Ternary complex of Kif2A-bound tandem tubulin heterodimers represents a kinesin-13-mediated microtubule depolymerization reaction intermediate.
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The kinesin-13 MCAK has an unconventional ATPase cycle adapted for microtubule depolymerization.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
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2011年學術文章
@zh-hant
name
The kinesin-13 MCAK has an unc ...... microtubule depolymerization.
@en
type
label
The kinesin-13 MCAK has an unc ...... microtubule depolymerization.
@en
prefLabel
The kinesin-13 MCAK has an unc ...... microtubule depolymerization.
@en
P2860
P356
P1433
P1476
The kinesin-13 MCAK has an unc ...... r microtubule depolymerization
@en
P2093
Claire T Friel
P2860
P304
P356
10.1038/EMBOJ.2011.290
P407
P577
2011-08-26T00:00:00Z