Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding.
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The hedgehog pathway in triple-negative breast cancerThe Role of Hedgehog Signaling in Tumor Induced Bone DiseaseIn smokers, Sonic hedgehog modulates pulmonary endothelial function through vascular endothelial growth factor.Hedgehog signaling pathway in colorectal cancer: function, mechanism, and therapy.Functional proteomics of the epigenetic regulators ASXL1, ASXL2 and ASXL3: a convergence of proteomics and epigenetics for translational medicine.GLI inhibitor GANT-61 diminishes embryonal and alveolar rhabdomyosarcoma growth by inhibiting Shh/AKT-mTOR axisMitochondria-derived reactive oxygen species drive GANT61-induced mesothelioma cell apoptosis.Synthetic Small Molecule Inhibitors of Hh Signaling As Anti-Cancer Chemotherapeutics.Evaluation of WO2014207069 A1: Multitarget Hedgehog pathway inhibitors and uses thereof.Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened.GLI1 orchestrates CXCR4/CXCR7 signaling to enhance migration and metastasis of breast cancer cells.Nanoquinacrine induced apoptosis in cervical cancer stem cells through the inhibition of hedgehog-GLI1 cascade: Role of GLI-1Hh/Gli antagonist in acute myeloid leukemia with CBFA2T3-GLIS2 fusion gene.Aberrant activation of hedgehog signaling promotes cell proliferation via the transcriptional activation of forkhead Box M1 in colorectal cancer cells.EGFR/ARF6 regulation of Hh signalling stimulates oncogenic Ras tumour overgrowth.Emerging from their burrow: Hedgehog pathway inhibitors for cancer.Targeting GLI by GANT61 involves mechanisms dependent on inhibition of both transcription and DNA licensing.Critical role of glioma-associated oncogene homolog 1 in maintaining invasive and mesenchymal-like properties of melanoma cellsGLI1 inhibitor GANT61 exhibits antitumor efficacy in T-cell lymphoma cells through down-regulation of p-STAT3 and SOCS3.Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma.GANT-61 and GDC-0449 induce apoptosis of prostate cancer stem cells through a GLI-dependent mechanism.Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells.A synthetic combinatorial approach to disabling deviant Hedgehog signaling.Gli is activated and promotes epithelial-mesenchymal transition in human esophageal adenocarcinoma.Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61.Role and inhibition of GLI1 protein in cancer.Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets
P2860
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P2860
Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
@yue
2014年學術文章
@zh
2014年學術文章
@zh-hant
name
Mode and specificity of bindin ...... inhibition of GLI-DNA binding.
@en
type
label
Mode and specificity of bindin ...... inhibition of GLI-DNA binding.
@en
prefLabel
Mode and specificity of bindin ...... inhibition of GLI-DNA binding.
@en
P2093
P2860
P356
P1433
P1476
Mode and specificity of bindin ...... inhibition of GLI-DNA binding
@en
P2093
Akwasi Agyeman
Janet A Houghton
Tapati Mazumdar
P2860
P304
P356
10.18632/ONCOTARGET.2046
P407
P577
2014-06-01T00:00:00Z