Novel combination of mitochondrial division inhibitor 1 (mdivi-1) and platinum agents produces synergistic pro-apoptotic effect in drug resistant tumor cells.
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Mitochondrial fission - a drug target for cytoprotection or cytodestruction?Mitochondrial targets for pharmacological intervention in human diseaseDownregulation of mitochondrial cyclooxygenase-2 inhibits the stemness of nasopharyngeal carcinoma by decreasing the activity of dynamin-related protein 1.Mdivi-1 induced acute changes in the angiogenic profile after ischemia-reperfusion injury in female mice.Mitochondrial division inhibitor 1 (mdivi-1) enhances death receptor-mediated apoptosis in human ovarian cancer cells.A novel strategy for targeted killing of tumor cells: Induction of multipolar acentrosomal mitotic spindles with a quinazolinone derivative mdivi-1.Mdivi-1, mitochondrial fission inhibitor, impairs developmental competence and mitochondrial function of embryos and cells in pigs.The combination of thioxodihydroquinazolinones and platinum drugs reverses platinum resistance in tumor cells by inducing mitochondrial apoptosis independent of Bax and BakQuantification of cellular viability by automated microscopy and flow cytometryDynamin-related protein Drp1 is required for Bax translocation to mitochondria in response to irradiation-induced apoptosisIncreased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways.Drp1-Dependent Mitochondrial Fission Plays Critical Roles in Physiological and Pathological Progresses in Mammals.Drp1-mediated mitochondrial fission promotes cell proliferation through crosstalk of p53 and NF-κB pathways in hepatocellular carcinoma.Mitochondrial dynamics regulating chemoresistance in gynecological cancers.To mdivi-1 or not to mdivi-1: Is that the question?Mitochondrial dynamics as regulators of cancer biology.Dynamin-related protein 1 mediates low glucose-induced endothelial dysfunction in human arterioles.DNA damage responsive miR-33b-3p promoted lung cancer cells survival and cisplatin resistance by targeting p21WAF1/CIP1.microRNA-488 inhibits chemoresistance of ovarian cancer cells by targeting Six1 and mitochondrial function.Melatonin enhances sorafenib actions in human hepatocarcinoma cells by inhibiting mTORC1/p70S6K/HIF-1α and hypoxia-mediated mitophagy.Inhibition of Mitochondrial Division Attenuates Cisplatin-Induced Toxicity in the Neuromast Hair Cells.Saikosaponin-d, a calcium mobilizing agent, sensitizes chemoresistant ovarian cancer cells to cisplatin-induced apoptosis by facilitating mitochondrial fission and G2/M arrest.Combination of a thioxodihydroquinazolinone with cisplatin eliminates ovarian cancer stem cell-like cells (CSC-LCs) and shows preclinical potential.Mitochondrial fission as a driver of stemness in tumor cells: mDIVI1 inhibits mitochondrial function, cell migration and cancer stem cell (CSC) signalling.Mitochondrial Dynamics in Type 2 Diabetes and Cancer.
P2860
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P2860
Novel combination of mitochondrial division inhibitor 1 (mdivi-1) and platinum agents produces synergistic pro-apoptotic effect in drug resistant tumor cells.
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2014 nî lūn-bûn
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2014年の論文
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
@zh-my
2014年学术文章
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2014年學術文章
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2014年學術文章
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2014年學術文章
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name
Novel combination of mitochond ...... in drug resistant tumor cells.
@en
type
label
Novel combination of mitochond ...... in drug resistant tumor cells.
@en
prefLabel
Novel combination of mitochond ...... in drug resistant tumor cells.
@en
P2093
P2860
P356
P1433
P1476
Novel combination of mitochond ...... in drug resistant tumor cells.
@en
P2093
Bennett Van Houten
Donna B Stolz
Fabien Llambi
Jingnan Wang
Lee A McDermott
Robert P Edwards
Vera Roginskaya
P2860
P304
P356
10.18632/ONCOTARGET.1944
P407
P577
2014-06-01T00:00:00Z