TDP-43 suppresses CGG repeat-induced neurotoxicity through interactions with HnRNP A2/B1.
about
Fragile X-associated tremor/ataxia syndrome.RNA-processing protein TDP-43 regulates FOXO-dependent protein quality control in stress responseFragile X-Associated Tremor/Ataxia Syndrome: From Molecular Pathogenesis to Development of Therapeutics.A fruitful endeavor: modeling ALS in the fruit flyThe hnRNP-Htt axis regulates necrotic cell death induced by transcriptional repression through impaired RNA splicing.Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALSTDP-43 functions within a network of hnRNP proteins to inhibit the production of a truncated human SORT1 receptor.Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation.Drosophila melanogaster As a Model Organism to Study RNA Toxicity of Repeat Expansion-Associated Neurodegenerative and Neuromuscular DiseasesProteome dynamics during postnatal mouse corpus callosum development.Molecular Pathophysiology of Fragile X-Associated Tremor/Ataxia Syndrome and Perspectives for Drug Development.RNA toxicity and foci formation in microsatellite expansion diseases.Long Noncoding RNAs and RNA-Binding Proteins in Oxidative Stress, Cellular Senescence, and Age-Related Diseases.Major hnRNP proteins act as general TDP-43 functional modifiers both in Drosophila and human neuronal cells.Genetic mutations in RNA-binding proteins and their roles in ALS.Genetic and Pathological Assessment of hnRNPA1, hnRNPA2/B1, and hnRNPA3 in Familial and Sporadic Amyotrophic Lateral Sclerosis.Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31.Repeat-associated non-AUG (RAN) translation and other molecular mechanisms in Fragile X Tremor Ataxia Syndrome.TDP-43 binds and transports G-quadruplex-containing mRNAs into neurites for local translation.Genetic variants in mRNA untranslated regions.Mechanistic View of hnRNPA2 Low-Complexity Domain Structure, Interactions, and Phase Separation Altered by Mutation and Arginine Methylation.
P2860
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P2860
TDP-43 suppresses CGG repeat-induced neurotoxicity through interactions with HnRNP A2/B1.
description
2014 nî lūn-bûn
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2014年の論文
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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name
TDP-43 suppresses CGG repeat-induced neurotoxicity through interactions with HnRNP A2/B1.
@en
type
label
TDP-43 suppresses CGG repeat-induced neurotoxicity through interactions with HnRNP A2/B1.
@en
prefLabel
TDP-43 suppresses CGG repeat-induced neurotoxicity through interactions with HnRNP A2/B1.
@en
P2093
P2860
P356
P1476
TDP-43 suppresses CGG repeat-induced neurotoxicity through interactions with HnRNP A2/B1.
@en
P2093
Brian D Freibaum
Peter K Todd
P2860
P304
P356
10.1093/HMG/DDU216
P577
2014-05-08T00:00:00Z