Targeting kidney CLC-K channels: pharmacological profile in a human cell line versus Xenopus oocytes.
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Therapeutic Approaches to Genetic Ion Channelopathies and Perspectives in Drug DiscoveryCLC channel function and dysfunction in health and disease.Human CLC-K Channels Require Palmitoylation of Their Accessory Subunit Barttin to Be FunctionalTryptophan Scanning Mutagenesis Identifies the Molecular Determinants of Distinct Barttin Functions.Dual regulation of the native ClC-K2 chloride channel in the distal nephron by voltage and pHRegulatory-auxiliary subunits of CLC chloride channel-transport proteins.Reduced Membrane Insertion of CLC-K by V33L Barttin Results in Loss of Hearing, but Leaves Kidney Function Intact.I-J loop involvement in the pharmacological profile of CLC-K channels expressed in Xenopus oocytes.Carboxyl-terminal Truncations of ClC-Kb Abolish Channel Activation by Barttin Via Modified Common Gating and Trafficking.Paving the way for Bartter syndrome type 3 drug discovery: a hope from basic research.Functional severity of CLCNKB mutations correlates with phenotypes in patients with classic Bartter's syndrome.Activation of renal ClC-K chloride channels depends on an intact N terminus of their accessory subunit barttin.Mapping ligand binding pockets in chloride ClC-1 channels through an integrated in silico and experimental approach using anthracene-9-carboxylic acid and niflumic acid.Pharmacovigilance database search discloses ClC-K channels as a novel target of the AT1 receptor blockers valsartan and olmesartan.
P2860
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P2860
Targeting kidney CLC-K channels: pharmacological profile in a human cell line versus Xenopus oocytes.
description
2014 nî lūn-bûn
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2014年の論文
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2014年学术文章
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2014年学术文章
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2014年学术文章
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name
Targeting kidney CLC-K channel ...... l line versus Xenopus oocytes.
@en
type
label
Targeting kidney CLC-K channel ...... l line versus Xenopus oocytes.
@en
prefLabel
Targeting kidney CLC-K channel ...... l line versus Xenopus oocytes.
@en
P50
P1476
Targeting kidney CLC-K channel ...... l line versus Xenopus oocytes.
@en
P2093
Diana Conte Camerino
P304
P356
10.1016/J.BBAMEM.2014.05.017
P407
P577
2014-05-24T00:00:00Z