The malaria parasite type II NADH:quinone oxidoreductase: an alternative enzyme for an alternative lifestyle.
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The structure of the yeast NADH dehydrogenase (Ndi1) reveals overlapping binding sites for water- and lipid-soluble substratesDiscovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assayReactions of antimalarial peroxides with each of leucomethylene blue and dihydroflavins: flavin reductase and the cofactor model exemplified.Identification of novel antimalarial chemotypes via chemoinformatic compound selection methods for a high-throughput screening program against the novel malarial target, PfNDH2: increasing hit rate via virtual screening methods.Variation among Plasmodium falciparum strains in their reliance on mitochondrial electron transport chain functionArrested oocyst maturation in Plasmodium parasites lacking type II NADH:ubiquinone dehydrogenase.Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors.Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malariaHDQ, a potent inhibitor of Plasmodium falciparum proliferation, binds to the quinone reduction site of the cytochrome bc1 complex.Glycerol: an unexpected major metabolite of energy metabolism by the human malaria parasite.A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activityTargeting the redox metabolism of Plasmodium falciparum.Novel inhibitors of the Plasmodium falciparum electron transport chain.The proliferating cell hypothesis: a metabolic framework for Plasmodium growth and development.The mitochondrial complex I of trypanosomatids--an overview of current knowledge.Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potentialA drug-selected Plasmodium falciparum lacking the need for conventional electron transportType-II NADH Dehydrogenase (NDH-2): a promising therapeutic target for antitubercular and antibacterial drug discovery.Targeting the mitochondrial electron transport chain of Plasmodium falciparum: new strategies towards the development of improved antimalarials for the elimination era.Expression, purification, crystallization and preliminary X-ray diffraction analysis of a type II NADH:quinone oxidoreductase from the human pathogen Staphylococcus aureus.Two internal type II NADH dehydrogenases of Toxoplasma gondii are both required for optimal tachyzoite growth.Type II NADH dehydrogenase inhibitor 1-hydroxy-2-dodecyl-4(1H)quinolone leads to collapse of mitochondrial inner-membrane potential and ATP depletion in Toxoplasma gondii.Interactions between artemisinins and other antimalarial drugs in relation to the cofactor model--a unifying proposal for drug action.A novel drug for uncomplicated malaria: targeted high throughput screening (HTS) against the type II NADH:ubiquinone oxidoreductase (PfNdh2) of Plasmodium falciparum.2-Pyridylquinolone antimalarials with improved antimalarial activity and physicochemical properties
P2860
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P2860
The malaria parasite type II NADH:quinone oxidoreductase: an alternative enzyme for an alternative lifestyle.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
The malaria parasite type II N ...... for an alternative lifestyle.
@en
The malaria parasite type II N ...... for an alternative lifestyle.
@nl
type
label
The malaria parasite type II N ...... for an alternative lifestyle.
@en
The malaria parasite type II N ...... for an alternative lifestyle.
@nl
prefLabel
The malaria parasite type II N ...... for an alternative lifestyle.
@en
The malaria parasite type II N ...... for an alternative lifestyle.
@nl
P2093
P921
P356
P1476
The malaria parasite type II N ...... for an alternative lifestyle.
@en
P2093
Nicholas Fisher
Patrick G Bray
Stephen A Ward
P304
P356
10.1016/J.PT.2007.04.014
P577
2007-05-10T00:00:00Z