Engineering of a bispecific affibody molecule towards HER2 and HER3 by addition of an albumin-binding domain allows for affinity purification and in vivo half-life extension.

Engineering of a bispecific affibody molecule towards HER2 and HER3 by addition of an albumin-binding domain allows for affinity purification and in vivo half-life extension.

Item
http://www.wikidata.org/entity/Q39010656
Fusion to a highly stable consensus albumin binding domain allows for tunable pharmacokineticsThe Use of Gene Ontology Term and KEGG Pathway Enrichment for Analysis of Drug Half-LifeEngineered Multivalency Enhances Affibody-Based HER3 Inhibition and Downregulation in Cancer CellsSimultaneous targeting of two ligand-binding sites on VEGFR2 using biparatopic Affibody molecules results in dramatically improved affinity.A truncated and dimeric format of an Affibody library on bacteria enables FACS-mediated isolation of amyloid-beta aggregation inhibitors with subnanomolar affinity.Improved in vivo anti-tumor effects of IgA-Her2 antibodies through half-life extension and serum exposure enhancement by FcRn targetingEvaluation of an Albumin-Binding Domain Protein Fused to Recombinant Human IL-2 and Its Effects on the Bioactivity and Serum Half-Life of the Cytokine.In vivo evaluation of a novel format of a bivalent HER3-targeting and albumin-binding therapeutic affibody construct.Novel affinity binders for neutralization of vascular endothelial growth factor (VEGF) signaling.Targeting HER3 using mono- and bispecific antibodies or alternative scaffolds.Affibody molecules as engineered protein drugs.In vivo biotinylation and incorporation of a photo-inducible unnatural amino acid to an antibody-binding domain improve site-specific labeling of antibodies.
P2860

Engineering of a bispecific affibody molecule towards HER2 and HER3 by addition of an albumin-binding domain allows for affinity purification and in vivo half-life extension.

Item
http://www.wikidata.org/entity/Q39010656
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Engineering of a bispecific af ...... d in vivo half-life extension.
@en
Engineering of a bispecific af ...... d in vivo half-life extension.
@nl
type
label
Engineering of a bispecific af ...... d in vivo half-life extension.
@en
Engineering of a bispecific af ...... d in vivo half-life extension.
@nl
prefLabel
Engineering of a bispecific af ...... d in vivo half-life extension.
@en
Engineering of a bispecific af ...... d in vivo half-life extension.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P5875
P698
P356
P1433
P1476
Engineering of a bispecific af ...... nd in vivo half-life extension
@en
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P5875
P698