Fisetin inhibits human melanoma cell growth through direct binding to p70S6K and mTOR: findings from 3-D melanoma skin equivalents and computational modeling - Wikidata - wikimedia - TriplyDB

Fisetin inhibits human melanoma cell growth through direct binding to p70S6K and mTOR: findings from 3-D melanoma skin equivalents and computational modeling

Fisetin inhibits human melanoma cell growth through direct binding to p70S6K and mTOR: findings from 3-D melanoma skin equivalents and computational modeling

http://www.wikidata.org/entity/Q39011116

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Phytochemicals for the Management of Melanoma Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors Novel cancer chemotherapy hits by molecular topology: dual Akt and Beta-catenin inhibitors Circulating microRNA-194 regulates human melanoma cells via PI3K/AKT/FoxO3a and p53/p21 signaling pathway.Targeting drivers of melanoma with synthetic small molecules and phytochemicals.Molecular mechanisms of flavonoids in melanin synthesis and the potential for the prevention and treatment of melanoma Combining fisetin and ionizing radiation suppresses the growth of mammalian colorectal cancers in xenograft tumor models.Systems Pharmacology-Based Discovery of Natural Products for Precision Oncology Through Targeting Cancer Mutated Genes.Fisetin, a dietary phytochemical, overcomes Erlotinib-resistance of lung adenocarcinoma cells through inhibition of MAPK and AKT pathways.Exploring the molecular targets of dietary flavonoid fisetin in cancer.Fisetin and Its Role in Chronic Diseases.Involvement of ER stress and activation of apoptotic pathways in fisetin induced cytotoxicity in human melanoma.Potential therapeutic targets of epithelial-mesenchymal transition in melanoma.Fisetin induces apoptosis and endoplasmic reticulum stress in human non-small cell lung cancer through inhibition of the MAPK signaling pathway.Fisetin Regulates Nrf2 Expression and the Inflammation-Related Signaling Pathway to Prevent UVB-Induced Skin Damage in Hairless Mice.Dual Inhibition of PI3K/Akt and mTOR by the Dietary Antioxidant, Delphinidin, Ameliorates Psoriatic Features In Vitro and in an Imiquimod-Induced Psoriasis-Like Disease in Mice.Inducers of Senescence, Toxic Compounds, and Senolytics: The Multiple Faces of Nrf2-Activating Phytochemicals in Cancer Adjuvant Therapy.Fisetin targets YB-1/RSK axis independent of its effect on ERK signaling: insights from in vitro and in vivo melanoma models Cold shock proteins: from cellular mechanisms to pathophysiology and disease

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P2860

Fisetin inhibits human melanoma cell growth through direct binding to p70S6K and mTOR: findings from 3-D melanoma skin equivalents and computational modeling

http://www.wikidata.org/entity/Q39011116

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2014 nî lūn-bûn

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Fisetin inhibits human melanom ...... nts and computational modeling

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Fisetin inhibits human melanom ...... ts and computational modeling.

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Fisetin inhibits human melanom ...... nts and computational modeling

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Fisetin inhibits human melanom ...... ts and computational modeling.

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Fisetin inhibits human melanom ...... nts and computational modeling

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Fisetin inhibits human melanom ...... ts and computational modeling.

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J.BCP.2014.03.007

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Biochemical Pharmacology

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Fisetin inhibits human melanom ...... nts and computational modeling

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Deeba N Syed

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Hasan Mukhtar

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Jean-Christopher Chamcheu

http://www.w3.org/2001/XMLSchema#string

Mohammad Imran Khan

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Rahul K Lall

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Vaqar M Adhami

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P2860

Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini

Inhibition of Akt/mTOR signaling by the dietary flavonoid fisetin

Fisetin: a dietary antioxidant for health promotion

A complex interplay between Akt, TSC2 and the two mTOR complexes

Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management

Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change

Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR

Structural Basis of Human p70 Ribosomal S6 Kinase-1 Regulation by Activation Loop Phosphorylation

Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP

Oncogenic kinase signalling

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