about
Teaching the basics of cancer metabolism: Developing antitumor strategies by exploiting the differences between normal and cancer cell metabolismMetabolic interactions in cancer: cellular metabolism at the interface between the microenvironment, the cancer cell phenotype and the epigenetic landscape.The Warburg Effect and Mass Spectrometry-based Proteomic Analysis.Role of the Transforming Growth Factor-β in regulating hepatocellular carcinoma oxidative metabolism.An engineered photoswitchable mammalian pyruvate kinase.Pyruvate kinase M2 phosphorylates H2AX and promotes genomic instability in human tumor cells.PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxy-D-glucose.Targeting Metabolism for Cancer Therapy.LincRNA-p21 suppresses development of human prostate cancer through inhibition of PKM2.Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis.Collateral Damage Intended-Cancer-Associated Fibroblasts and Vasculature Are Potential Targets in Cancer Therapy.Effects of shRNA-Mediated Silencing of PKM2 Gene on Aerobic Glycolysis, Cell Migration, Cell Invasion, and Apoptosis in Colorectal Cancer Cells.The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centers.Synthesis and antitumor activity of novel 2, 3-didithiocarbamate substituted naphthoquinones as inhibitors of pyruvate kinase M2 isoform.Pyruvate kinase M2 fuels multiple aspects of cancer cells: from cellular metabolism, transcriptional regulation to extracellular signaling.O-GlcNAcylation destabilizes the active tetrameric PKM2 to promote the Warburg effect.Oncogenic kinase-induced PKM2 tyrosine 105 phosphorylation converts non-oncogenic PKM2 to a tumor promoter and induces cancer stem-like cells.Alternative-splicing defects in cancer: Splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics.Natural Product Micheliolide (MCL) Irreversibly Activates Pyruvate Kinase M2 and Suppresses Leukemia.The Warburg Effect in Diabetic Kidney Disease.Overexpressed genes in malignant pleural mesothelioma: implications in clinical management.The Role for Myc in Coordinating Glycolysis, Oxidative Phosphorylation, Glutaminolysis, and Fatty Acid Metabolism in Normal and Neoplastic Tissues.Adaptations in energy metabolism and gene family expansions revealed by comparative transcriptomics of three Chagas disease triatomine vectors.Metabolic Reprogramming in Thyroid Carcinoma.Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma.Signaling Pathways Regulating Redox Balance in Cancer Metabolism.Organ-Specific MicroRNAs (MIR122, 137, and 206) Contribute to Tissue Characteristics and Carcinogenesis by Regulating Pyruvate Kinase M1/2 (PKM) Expression.PKM2 is not required for pancreatic ductal adenocarcinomaThe Multifarious Functions of Pyruvate Kinase M2 in Oral Cancer Cells
P2860
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P2860
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
PKM2, cancer metabolism, and the road ahead.
@en
PKM2, cancer metabolism, and the road ahead.
@nl
type
label
PKM2, cancer metabolism, and the road ahead.
@en
PKM2, cancer metabolism, and the road ahead.
@nl
prefLabel
PKM2, cancer metabolism, and the road ahead.
@en
PKM2, cancer metabolism, and the road ahead.
@nl
P2860
P356
P1433
P1476
PKM2, cancer metabolism, and the road ahead.
@en
P2093
Talya L Dayton
Tyler Jacks
P2860
P304
P356
10.15252/EMBR.201643300
P577
2016-11-17T00:00:00Z