Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex - Wikidata - wikimedia - TriplyDB

Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex

Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex

http://www.wikidata.org/entity/Q39028348

about

Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity Targeting Tumor Metabolism for Cancer Treatment: Is Pyruvate Dehydrogenase Kinases (PDKs) a Viable Anticancer Target?6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling What is good for the circulation also lessens cancer risk SIRT3 regulates progression and development of diseases of aging.Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases Defining the orphan functions of lysine acetyltransferases PGC-1α and fasting-induced PDH regulation in mouse skeletal muscle Expression proteomics study to determine metallodrug targets and optimal drug combinations.The pyruvate dehydrogenase complexes: structure-based function and regulation.Sirtuins: guardians of mammalian healthspan.Inhibition of 6-phosphogluconate Dehydrogenase Reverses Cisplatin Resistance in Ovarian and Lung Cancer Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth.Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth.Tyr-301 phosphorylation inhibits pyruvate dehydrogenase by blocking substrate binding and promotes the Warburg effect.Mitochondrial sirtuins and their relationships with metabolic disease and cancer.Combined evaluation of hexokinase 2 and phosphorylated pyruvate dehydrogenase-E1α in invasive front lesions of colorectal tumors predicts cancer metabolism and patient prognosis.The ɛ-Amino Group of Protein Lysine Residues Is Highly Susceptible to Nonenzymatic Acylation by Several Physiological Acyl-CoA Thioesters.Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling Using mitochondrial sirtuins as drug targets: disease implications and available compounds.Analysis of acetylation stoichiometry suggests that SIRT3 repairs nonenzymatic acetylation lesions.The Mitochondrial Basis of Aging.Mitochondrial protein hyperacetylation in the failing heart Hypoxic repression of pyruvate dehydrogenase activity is necessary for metabolic reprogramming and growth of model tumours.Phosphorylation of the pyruvate dehydrogenase complex precedes HIF-1-mediated effects and pyruvate dehydrogenase kinase 1 upregulation during the first hours of hypoxic treatment in hepatocellular carcinoma cells.Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders Role of CoA and acetyl-CoA in regulating cardiac fatty acid and glucose oxidation.The pyruvate dehydrogenase complex in cancer: An old metabolic gatekeeper regulated by new pathways and pharmacological agents.Chicken or the egg: Warburg effect and mitochondrial dysfunction.Protein acetylation in metabolism - metabolites and cofactors.Chemical Biology for Investigating Epigenetic Functions of Lysine Acetyltransferases (KATs).Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor Growth.Histone Modifications and Cancer.Impact of acetylation on tumor metabolism.Metabolic control of epigenetics in cancer.KATapulting toward Pluripotency and Cancer.Cell-surface G-protein-coupled receptors for tumor-associated metabolites: A direct link to mitochondrial dysfunction in cancer.Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome.Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients.

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P2860

Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex

http://www.wikidata.org/entity/Q39028348

description

2014 nî lūn-bûn

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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2014年论文

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2014年论文

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name

Tyr phosphorylation of PDP1 to ...... pyruvate dehydrogenase complex

@en

Tyr phosphorylation of PDP1 to ...... yruvate dehydrogenase complex.

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type

label

Tyr phosphorylation of PDP1 to ...... pyruvate dehydrogenase complex

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Tyr phosphorylation of PDP1 to ...... yruvate dehydrogenase complex.

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prefLabel

Tyr phosphorylation of PDP1 to ...... pyruvate dehydrogenase complex

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Tyr phosphorylation of PDP1 to ...... yruvate dehydrogenase complex.

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J.MOLCEL.2013.12.026

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Tyr phosphorylation of PDP1 to ...... pyruvate dehydrogenase complex

@en

P2093

Benjamin A Garcia

http://www.w3.org/2001/XMLSchema#string

Changliang Shan

http://www.w3.org/2001/XMLSchema#string

Fadlo R Khuri

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Hanna J Khoury

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Hee-Bum Kang

http://www.w3.org/2001/XMLSchema#string

Huaibin Chen

http://www.w3.org/2001/XMLSchema#string

Jae Ho Seo

http://www.w3.org/2001/XMLSchema#string

Jianxin Xie

http://www.w3.org/2001/XMLSchema#string

Jing Chen

http://www.w3.org/2001/XMLSchema#string

Jun Fan

http://www.w3.org/2001/XMLSchema#string

P2860

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways

Regulation of cellular metabolism by protein lysine acetylation

Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism

Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth

Lysine-5 acetylation negatively regulates lactate dehydrogenase A and is decreased in pancreatic cancer

SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress

Understanding the Warburg effect: the metabolic requirements of cell proliferation

Fibroblast growth factor (FGF) and FGF receptor-mediated autocrine signaling in non-small-cell lung cancer cells

Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1

Lysine acetylation targets protein complexes and co-regulates major cellular functions

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534-548

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10.1016/J.MOLCEL.2013.12.026

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4

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53

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Erwin G Van Meir

Moosa Mohammadi

Maša Alečković

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2014-01-30T00:00:00Z

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260023352

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24486017

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phosphorylation

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3943932

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