The combination of RAD001 and MK-2206 exerts synergistic cytotoxic effects against PTEN mutant gastric cancer cells: involvement of MAPK-dependent autophagic, but not apoptotic cell death pathway.
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Ulk1 over-expression in human gastric cancer is correlated with patients' T classification and cancer relapse.Transforming growth factor-β1 (TGF-β1) induces mouse precartilaginous stem cell proliferation through TGF-β receptor II (TGFRII)-Akt-β-catenin signaling.The Role of PI3K/Akt/mTOR Signaling in Gastric Carcinoma.Squamosamide derivative FLZ protects retinal pigment epithelium cells from oxidative stress through activation of epidermal growth factor receptor (EGFR)-AKT signaling.Successful control of heavily pretreated metastatic gastric cancer with the mTOR inhibitor everolimus (RAD001) in a patient with PIK3CA mutation and pS6 overexpressionCC-223 blocks mTORC1/C2 activation and inhibits human hepatocellular carcinoma cells in vitro and in vivo.Expression and clinical significance of Beclin-1 in gastric cancer tissues of various clinical stagesG-protein coupled receptor 34 knockdown impairs the proliferation and migration of HGC-27 gastric cancer cells in vitroFunctional role of autophagy in gastric cancer.Integrated in vivo genetic and pharmacologic screening identifies co-inhibition of EGRF and ROCK as a potential treatment regimen for triple-negative breast cancer.Effects of U0126 and MK2206 on cell growth and re-growth of endometriotic stromal cells grown on substrates of varying stiffnessK-Ras mutation and amplification status is predictive of resistance and high basal pAKT is predictive of sensitivity to everolimus in biliary tract cancer cell lines.Reactive nitrogen species as therapeutic targets for autophagy: implication for ischemic stroke.The dual targeting of insulin and insulin-like growth factor 1 receptor enhances the mTOR inhibitor-mediated antitumor efficacy in hepatocellular carcinoma.Celecoxib sensitizes gastric cancer to rapamycin via inhibition of the Cbl-b-regulated PI3K/Akt pathway.MK-2206 co-treatment with 5-fluorouracil or doxorubicin enhances chemosensitivity and apoptosis in gastric cancer by attenuation of Akt phosphorylation.Vertical inhibition of the PI3K/Akt/mTOR pathway is synergistic in breast cancer.The irreversible ERBB1/2/4 inhibitor neratinib interacts with the PARP1 inhibitor niraparib to kill ovarian cancer cells.SC79 protects dopaminergic neurons from oxidative stress.Curcuminoid EF24 enhances the anti-tumour activity of Akt inhibitor MK-2206 through ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction in gastric cancer.
P2860
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P2860
The combination of RAD001 and MK-2206 exerts synergistic cytotoxic effects against PTEN mutant gastric cancer cells: involvement of MAPK-dependent autophagic, but not apoptotic cell death pathway.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
The combination of RAD001 and ...... apoptotic cell death pathway.
@en
The combination of RAD001 and ...... apoptotic cell death pathway.
@nl
type
label
The combination of RAD001 and ...... apoptotic cell death pathway.
@en
The combination of RAD001 and ...... apoptotic cell death pathway.
@nl
prefLabel
The combination of RAD001 and ...... apoptotic cell death pathway.
@en
The combination of RAD001 and ...... apoptotic cell death pathway.
@nl
P2093
P2860
P921
P1433
P1476
The combination of RAD001 and ...... apoptotic cell death pathway.
@en
P2093
Biqiang Zheng
Chenchen Wang
Dongmei Ji
Jinjia Chang
Rongliang Zheng
Rujiao Liu
Shanshan Wang
Xiaofeng Wang
P2860
P304
P356
10.1371/JOURNAL.PONE.0085116
P407
P577
2014-01-09T00:00:00Z