Generation of a mouse model of Von Hippel-Lindau kidney disease leading to renal cancers by expression of a constitutively active mutant of HIF1α.
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Renal tubular HIF-2α expression requires VHL inactivation and causes fibrosis and cystsMesoscale nanoparticles selectively target the renal proximal tubule epitheliumMolecular mechanisms of ischemic preconditioning in the kidneyThe SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma.VHL, the story of a tumour suppressor gene.Genome-Wide Profiling of TRACK Kidneys Shows Similarity to the Human ccRCC Transcriptome.Analyses of the transcriptome and metabolome demonstrate that HIF1α mediates altered tumor metabolism in clear cell renal cell carcinoma.Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways.Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypes.WSB1 promotes tumor metastasis by inducing pVHL degradationAnthracycline inhibits recruitment of hypoxia-inducible transcription factors and suppresses tumor cell migration and cardiac angiogenic response in the host.Role of NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex 4-Like 2 in Clear Cell Renal Cell CarcinomaCRISPR-Mediated VHL Knockout Generates an Improved Model for Metastatic Renal Cell Carcinoma.Establishment of a large panel of patient-derived preclinical models of human renal cell carcinomaAngiogenesis and autosomal dominant polycystic kidney disease.Tumor hypoxia as a driving force in genetic instability.The role of HIF1α in renal cell carcinoma tumorigenesis.Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium.Genetic modification of hypoxia signaling in animal models and its effect on cancer.Expanding roles of the hypoxia-response network in chronic kidney disease.PD-L1 expression is regulated by hypoxia inducible factor in clear cell renal cell carcinoma.Reduced cilia frequencies in human renal cell carcinomas versus neighboring parenchymal tissue.Activation of HIF2α in kidney proximal tubule cells causes abnormal glycogen deposition but not tumorigenesis.Kidney-specific knockout of Sav1 in the mouse promotes hyperproliferation of renal tubular epithelium through suppression of the Hippo pathway.Simultaneous targeted activation of Notch1 and Vhl-disruption in the kidney proximal epithelial tubular cells in mice.Constitutive expression of HIF-α plays a major role in generation of clear-cell phenotype in human primary and metastatic renal carcinoma.Loss of PBRM1 rescues VHL dependent replication stress to promote renal carcinogenesis.Correlation of quantitative parameters of magnetic resonance perfusion-weighted imaging with vascular endothelial growth factor, microvessel density and hypoxia-inducible factor-1α in nasopharyngeal carcinoma: Evaluation on radiosensitivity study.The HIF and other quandaries in VHL disease.Renal Cell Carcinoma in von Hippel-Lindau Disease-From Tumor Genetics to Novel Therapeutic Strategies.The von Hippel-Lindau tumor suppressor regulates programmed cell death 5-mediated degradation of Mdm2.Acute kidney injury induces hallmarks of polycystic kidney disease.Generation of autochthonous mouse models of clear cell renal cell carcinoma: mouse models of renal cell carcinoma.Kidney cancer: Novel targets in altered tumour metabolism in kidney cancer.A 3D Human Renal Cell Carcinoma-on-a-Chip for the Study of Tumor Angiogenesis.
P2860
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P2860
Generation of a mouse model of Von Hippel-Lindau kidney disease leading to renal cancers by expression of a constitutively active mutant of HIF1α.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Generation of a mouse model of ...... tively active mutant of HIF1α.
@en
Generation of a mouse model of ...... tively active mutant of HIF1α.
@nl
type
label
Generation of a mouse model of ...... tively active mutant of HIF1α.
@en
Generation of a mouse model of ...... tively active mutant of HIF1α.
@nl
prefLabel
Generation of a mouse model of ...... tively active mutant of HIF1α.
@en
Generation of a mouse model of ...... tively active mutant of HIF1α.
@nl
P2093
P2860
P1433
P1476
Generation of a mouse model of ...... tively active mutant of HIF1α.
@en
P2093
David M Nanus
Leiping Fu
Lorraine J Gudas
Maria M Shevchuk
P2860
P304
P356
10.1158/0008-5472.CAN-11-1745
P407
P577
2011-09-09T00:00:00Z