Controlling long-term signaling: receptor dynamics determine attenuation and refractory behavior of the TGF-β pathway.
about
Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathwaySignal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states.Caveolin-1 is required for TGF-β-induced transactivation of the EGF receptor pathway in hepatocytes through the activation of the metalloprotease TACE/ADAM17.Response to Nodal morphogen gradient is determined by the kinetics of target gene induction.A Temporal Window for Signal Activation Dictates the Dimensions of a Nodal Signaling Domain.Discrete spatial organization of TGFβ receptors couples receptor multimerization and signaling to cellular tensionMembrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signalingDemystifying the cytokine network: Mathematical models point the way.Identifying Mechanisms of Homeostatic Signaling in Fibroblast Differentiation.Induction of senescence in primary glioblastoma cells by serum and TGFβ.PKCθ links proximal T cell and Notch signaling through localized regulation of the actin cytoskeleton'Molecular habituation' as a potential mechanism of gradual homeostatic loss with age.Spatiotemporal Control of TGF-β Signaling with Light.Cell-specific responses to the cytokine TGFβ are determined by variability in protein levels.TGF-β and IL-6 family signalling crosstalk: an integrated model.TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms.TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition.Response to comment on "Controlling long-term signaling: receptor dynamics determine attenuation and refractory behavior of the TGF-β pathway"-Smad2/3 activity does not predict the dynamics of transcription.Reduced SMAD2/3 activation independently predicts increased depth of human cutaneous squamous cell carcinoma.2013: Signaling breakthroughs of the year.Comment on "Controlling long-term signaling: receptor dynamics determine attenuation and refractory behavior of the TGF-β pathway"-Smad2/3 activity does not predict the dynamics of transcription.Pathway crosstalk enables cells to interpret TGF-β duration.Signaling pathways as linear transmitters
P2860
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P2860
Controlling long-term signaling: receptor dynamics determine attenuation and refractory behavior of the TGF-β pathway.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Controlling long-term signalin ...... behavior of the TGF-β pathway.
@en
Controlling long-term signalin ...... behavior of the TGF-β pathway.
@nl
type
label
Controlling long-term signalin ...... behavior of the TGF-β pathway.
@en
Controlling long-term signalin ...... behavior of the TGF-β pathway.
@nl
prefLabel
Controlling long-term signalin ...... behavior of the TGF-β pathway.
@en
Controlling long-term signalin ...... behavior of the TGF-β pathway.
@nl
P2860
P50
P1433
P1476
Controlling long-term signalin ...... behavior of the TGF-β pathway
@en
P2093
Debipriya Das
Ilaria Gori
P2860
P356
10.1126/SCISIGNAL.2004416
P577
2013-12-10T00:00:00Z