about
Signal peptide cleavage and internal targeting signals direct the hepatitis C virus p7 protein to distinct intracellular membranes.Determinants of Hepatitis C Virus p7 Ion Channel Function and Drug Sensitivity Identified In VitroPlugging the holes in hepatitis C virus antiviral therapySuppression of a pro-apoptotic K+ channel as a mechanism for hepatitis C virus persistenceA Conserved Proline between Domains II and III of Hepatitis C Virus NS5A Influences both RNA Replication and Virus AssemblyStructure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion releaseGenotype-specific differences in structural features of hepatitis C virus (HCV) p7 membrane protein.Inhibition of hepatitis C virus p7 membrane channels in a liposome-based assay system.Intracellular proton conductance of the hepatitis C virus p7 protein and its contribution to infectious virus productionHigh-risk human papillomavirus E5 oncoprotein displays channel-forming activity sensitive to small-molecule inhibitors.NS2 is dispensable for efficient assembly of hepatitis C virus-like particles in a bipartite trans-encapsidation system.Identification of a novel phosphorylation site in hepatitis C virus NS5AThe subcellular localization of the hepatitis C virus non-structural protein NS2 is regulated by an ion channel-independent function of the p7 proteinA novel method for the measurement of hepatitis C virus infectious titres using the IncuCyte ZOOM and its application to antiviral screeningHepatitis C virus-induced autophagy is independent of the unfolded protein response.Ion Channel Function and Cross-Species Determinants in Viral Assembly of Nonprimate Hepacivirus p7Progress in clinical oncolytic virus-based therapy for hepatocellular carcinoma.Viroporins: structure, function and potential as antiviral targets.The stability of secreted, acid-labile H77/JFH-1 hepatitis C virus (HCV) particles is altered by patient isolate genotype 1a p7 sequences."Too little, too late?" Will inhibitors of the hepatitis C virus p7 ion channel ever be used in the clinic?Mutations in hepatitis C virus p7 reduce both the egress and infectivity of assembled particles via impaired proton channel function.Resistance mutations define specific antiviral effects for inhibitors of the hepatitis C virus p7 ion channel.Internalization of oncolytic reovirus by human dendritic cell carriers protects the virus from neutralization.The major human immunodeficiency virus type 2 (HIV-2) packaging signal is present on all HIV-2 RNA species: cotranslational RNA encapsidation and limitation of Gag protein confer specificity.Vps4 and the ESCRT-III complex are required for the release of infectious hepatitis C virus particles.Expression of hepatitis C virus (HCV) structural proteins in trans facilitates encapsidation and transmission of HCV subgenomic RNA.Chimeric GB virus B genomes containing hepatitis C virus p7 are infectious in vivo.Genotype-dependent sensitivity of hepatitis C virus to inhibitors of the p7 ion channel.The hepatitis C virus non-structural protein NS5A alters the trafficking profile of the epidermal growth factor receptor.Evidence for the formation of a heptameric ion channel complex by the hepatitis C virus p7 protein in vitro.Tagging of NS5A expressed from a functional hepatitis C virus replicon.A link between translation of the hepatitis C virus polyprotein and polymerase function; possible consequences for hyperphosphorylation of NS5A.Oncolytic reovirus as a combined antiviral and anti-tumour agent for the treatment of liver cancer.A conserved basic loop in hepatitis C virus p7 protein is required for amantadine-sensitive ion channel activity in mammalian cells but is dispensable for localization to mitochondria.Release of Infectious Hepatitis C Virus from Huh7 Cells Occurs via a trans-Golgi Network-to-Endosome Pathway Independent of Very-Low-Density Lipoprotein Secretion.Small molecule ligand docking to genotype specific bundle structures of hepatitis C virus (HCV) p7 protein.Direct visualization of the small hydrophobic protein of human respiratory syncytial virus reveals the structural basis for membrane permeability.Domain III of NS5A contributes to both RNA replication and assembly of hepatitis C virus particles.Nucleotide requirements at positions +1 to +4 for the initiation of hepatitis C virus positive-strand RNA synthesis.Genetic and functional heterogeneity of the hepatitis C virus p7 ion channel during natural chronic infection.
P50
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P50
description
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wetenschapper
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հետազոտող
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Stephen Griffin
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Stephen Griffin
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Stephen Griffin
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Stephen Griffin
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Stephen Griffin
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Stephen Griffin
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Stephen Griffin
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Stephen Griffin
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Stephen Griffin
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Stephen Griffin
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Steve Griffin
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Stephen Griffin
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Stephen Griffin
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Stephen Griffin
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Stephen Griffin
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Stephen Griffin
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P106
P21
P31
P496
0000-0002-7233-5243