about
Structural insights into mechanisms of catalysis and inhibition in Norwalk virus polymeraseSensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosidesNovel acid-activated fluorophores reveal a dynamic wave of protons in the intestine of Caenorhabditis elegansRapid detection of protein tyrosine kinase activity in recombinant yeast expressing a universal substrate.Synthesis of a beta-estradiol-biotin chimera that potently heterodimerizes estrogen receptor and streptavidin proteins in a yeast three-hybrid system.Fluorescence-based cloning of a protein tyrosine kinase with a yeast tribrid system.Chemico-genetic identification of drebrin as a regulator of calcium responsesSynthesis of a 6-methyl-7-deaza analogue of adenosine that potently inhibits replication of polio and dengue virusesDevelopment of a cell-based, high-throughput screening assay for cholesterol efflux using a fluorescent mimic of cholesterol.Augmenting vitamin D to combat genetic disease.Anticancer/antiviral agent Akt inhibitor-IV massively accumulates in mitochondria and potently disrupts cellular bioenergetics.Synthesis of Fluorophores that Target Small Molecules to the Endoplasmic Reticulum of Living Mammalian Cells.Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometryA critical arginine residue mediates cooperativity in the contact interface between transcription factors NFAT and AP-1Lethal mutagenesis of poliovirus mediated by a mutagenic pyrimidine analogue.Synthesis and antiviral activity of 5-substituted cytidine analogues: identification of a potent inhibitor of viral RNA-dependent RNA polymerases.Fluorescent mimics of cholesterol that rapidly bind surfaces of living mammalian cells.Lethal mutagenesis of picornaviruses with N-6-modified purine nucleoside analogues.Small-molecule triggers of tadpole metamorphosis.The orientation of the AP-1 heterodimer on DNA strongly affects transcriptional potency.The Pennsylvania Green Fluorophore: a hybrid of Oregon Green and Tokyo Green for the construction of hydrophobic and pH-insensitive molecular probes.Cavity depth and width effects on cyclophane-steroid recognition: molecular complexation of cholesterol and progesterone in aqueous solution.Practical synthesis of 3beta-amino-5-cholestene and related 3beta-halides involving i-steroid and retro-i-steroid rearrangementsDetection of protein-protein interactions by proximity-driven S(N)Ar reactions of lysine-linked fluorophores.Structural requirements for the inhibition of calcium mobilization and mast cell activation by the pyrazole derivative BTP2.Synthesis and biological evaluation of analogues of AKT (protein kinase B) inhibitor-IV.Synthesis of fluorinated benzophenones, xanthones, acridones, and thioxanthones by iterative nucleophilic aromatic substitution.Efficient and Scalable Synthesis of 4-Carboxy-Pennsylvania Green Methyl Ester: A Hydrophobic Building Block for Fluorescent Molecular ProbesCalcium flux in neuroblastoma cells is a coupling mechanism between non-genomic and genomic modes of estrogens.Quantification of Small Molecule-Protein Interactions using FRET between Tryptophan and the Pacific Blue Fluorophore.11beta-alkyl-Delta9-19-nortestosterone derivatives: high-affinity ligands and potent partial agonists of the androgen receptor.Interaction of 3β-amino-5-cholestene with phospholipids in binary and ternary bilayer membranes.A synthetic mimic of human Fc receptors: defined chemical modification of cell surfaces enables efficient endocytic uptake of human immunoglobulin-G.Selective disruption of early/recycling endosomes: release of disulfide-linked cargo mediated by a N-alkyl-3beta-cholesterylamine-capped peptide.Endocytic delivery of vancomycin mediated by a synthetic cell surface receptor: rescue of bacterially infected Mammalian cells and tissue targeting in vivo.Synthesis of a universal 5-nitroindole ribonucleotide and incorporation into RNA by a viral RNA-dependent RNA polymerase.Human neutrophil peptides mediate endothelial-monocyte interaction, foam cell formation, and platelet activation.Synthesis of an artificial cell surface receptor that enables oligohistidine affinity tags to function as metal-dependent cell-penetrating peptidesEfficient delivery of streptavidin to mammalian cells: clathrin-mediated endocytosis regulated by a synthetic ligand.Synthesis and antiviral evaluation of a mutagenic and non-hydrogen bonding ribonucleoside analogue: 1-beta-D-Ribofuranosyl-3-nitropyrrole.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Blake R Peterson
@nl
Blake R Peterson
@sl
Blake R. Peterson
@en
Blake R. Peterson
@es
type
label
Blake R Peterson
@nl
Blake R Peterson
@sl
Blake R. Peterson
@en
Blake R. Peterson
@es
prefLabel
Blake R Peterson
@nl
Blake R Peterson
@sl
Blake R. Peterson
@en
Blake R. Peterson
@es
P1053
O-2497-2016
P106
P1153
7401664298
P21
P31
P3829
P496
0000-0001-8251-3579