about
The LIM-only protein LMO4 modulates the transcriptional activity of HEN1The BH3-only protein Puma plays an essential role in cytokine deprivation induced apoptosis of mast cellsCharacterization, chromosomal localization, and expression during hematopoietic differentiation of the gene encoding Arl6ip, ADP-ribosylation-like factor-6 interacting protein (ARL6)The Q705K polymorphism in NLRP3 is a gain-of-function alteration leading to excessive interleukin-1β and IL-18 production.Bcl11b mutations identified in murine lymphomas increase the proliferation rate of hematopoietic progenitor cells.Deficiency of activating Fcγ-receptors reduces hepatic clearance and deposition of IC and increases CIC levels in mercury-induced autoimmunity.Pyruvate dehydrogenase kinase 1 is essential for transplantable mouse bone marrow hematopoietic stem cell and progenitor functionABCB1 haplotypes do not influence transport or efficacy of tyrosine kinase inhibitors in vitroThe hematopoietic stem cell niche: low in oxygen but a nice place to be.miR-20b regulates expression of proteinase-activated receptor-1 (PAR-1) thrombin receptor in melanoma cells.Single-nucleotide polymorphisms of ABCG2 increase the efficacy of tyrosine kinase inhibitors in the K562 chronic myeloid leukemia cell line.The pan-ErbB tyrosine kinase inhibitor canertinib induces caspase-mediated cell death in human T-cell leukemia (Jurkat) cells.Interleukin-7-induced Stat-5 acts in synergy with Flt-3 signaling to stimulate expansion of hematopoietic progenitor cells.BH3-only protein Bim more critical than Puma in tyrosine kinase inhibitor-induced apoptosis of human leukemic cells and transduced hematopoietic progenitors carrying oncogenic FLT3.Interleukin-6 primarily produced by non-hematopoietic cells mediates the lipopolysaccharide-induced febrile response.Lipopolysaccharide-induced fever depends on prostaglandin E2 production specifically in brain endothelial cells.FLT3 ligand regulates apoptosis through AKT-dependent inactivation of transcription factor FoxO3.The basic helix-loop-helix transcription factor TAL1/SCL inhibits the expression of the p16INK4A and pTalpha genes.Phosphatidylinositol 3-kinase is essential for kit ligand-mediated survival, whereas interleukin-3 and flt3 ligand induce expression of antiapoptotic Bcl-2 family genes.Inactivation of the forkhead transcription factor FoxO3 is essential for PKB-mediated survival of hematopoietic progenitor cells by kit ligand.The pan-ErbB receptor tyrosine kinase inhibitor canertinib induces ErbB-independent apoptosis in human leukemia (HL-60 and U-937) cells.The regulatory domain of protein kinase Ctheta localises to the Golgi complex and induces apoptosis in neuroblastoma and Jurkat cells.Systemic reduction of functionally suppressive CD4dimCD25highFoxp3+ Tregs in human second trimester pregnancy is induced by progesterone and 17beta-estradiol.Stem cell factor promotes mast cell survival via inactivation of FOXO3a-mediated transcriptional induction and MEK-regulated phosphorylation of the proapoptotic protein Bim.Coexpression of hyperactivated AKT1 with additional genes activated in leukemia drives hematopoietic progenitor cells to cell cycle block and apoptosis.The Lim-only protein LMO2 acts as a positive regulator of erythroid differentiation.Irreversible pan-ERBB inhibitor canertinib elicits anti-leukaemic effects and induces the regression of FLT3-ITD transformed cells in mice.IL-7 mediates Ebf-1-dependent lineage restriction in early lymphoid progenitors.Characterization of the mouse myeloid-associated differentiation marker (MYADM) gene: promoter analysis and protein localization.Interleukin-1β induced activation of the hypothalamus-pituitary-adrenal axis is dependent on interleukin-1 receptors on non-hematopoietic cells.Hypoxia mediates low cell-cycle activity and increases the proportion of long-term-reconstituting hematopoietic stem cells during in vitro culture.Interleukin-7 responsiveness of B220+ B cell precursors from bone marrow decreases in aging miceFlt3 ligand induces the outgrowth of Mac-1+B220+ mouse bone marrow progenitor cells restricted to macrophage differentiation that coexpress early B cell-associated genesAbsence of hot spot mutations of the PIK3CA gene in acute myeloid leukaemiaHypoxic and normoxic in vitro cultures maintain similar numbers of long-term reconstituting hematopoietic stem cells from mouse bone marrowKnockdown of peroxisome proliferator-activated receptor-beta induces less differentiation and enhances cell-fibronectin adhesion of colon cancer cells
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description
hulumtues
@sq
researcher
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wetenschapper
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հետազոտող
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Jan-Ingvar Jönsson
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Jan-Ingvar Jönsson
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Jan-Ingvar Jönsson
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Jan-Ingvar Jönsson
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Jan-Ingvar Jönsson
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Jan-Ingvar Jönsson
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Jan-Ingvar Jönsson
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Jan-Ingvar Jönsson
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Jan-Ingvar Jönsson
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Jan-Ingvar Jönsson
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Jan-Ingvar Jönsson
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Jan-Ingvar Jönsson
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Jan-Ingvar Jönsson
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Jan-Ingvar Jönsson
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Jan-Ingvar Jönsson
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P106
P1153
7102222977
P21
P31
P496
0000-0003-4814-978X