A small molecule AMPK activator protects the heart against ischemia-reperfusion injury.
about
Dissecting the role of AMP-activated protein kinase in human diseases.Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart.The beneficial effects of AMP kinase activation against oxidative stress are associated with prevention of PPARα-cyclophilin D interaction in cardiomyocytes.Phosphatase and tensin homolog-induced putative kinase 1 and Parkin in diabetic heart: Role of mitophagy.AMP-Activated Protein Kinase Regulates the Cell Surface Proteome and Integrin Membrane Traffic.5'-AMP Activated Protein Kinase is Involved in the Regulation of Myocardial β-Oxidative Capacity in Mice.Repetitive stimulation of autophagy-lysosome machinery by intermittent fasting preconditions the myocardium to ischemia-reperfusion injury.Targeting AMPK: From Ancient Drugs to New Small-Molecule Activators.Mitochondria as a drug target in ischemic heart disease and cardiomyopathyAlpha1 catalytic subunit of AMPK modulates contractile function of cardiomyocytes through phosphorylation of troponin I.Possible Role of Interaction between PPARα and Cyclophilin D in Cardioprotection of AMPK against In Vivo Ischemia-Reperfusion in RatsAMPK is critical for mitochondrial function during reperfusion after myocardial ischemia.AMPK Activators as a Drug for Diabetes, Cancer and Cardiovascular DiseaseLimiting cardiac ischemic injury by pharmacological augmentation of macrophage migration inhibitory factor-AMP-activated protein kinase signal transduction.Urocortin 2 autocrine/paracrine and pharmacologic effects to activate AMP-activated protein kinase in the heart.PR65A phosphorylation regulates PP2A complex signaling.Effect of A-769662, a direct AMPK activator, on Tlr-4 expression and activity in mice heart tissue.AMP-activated protein kinase: new regulation, new roles?AMP-activated protein kinase: an emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseasesAMP-activated protein kinase regulation and biological actions in the heart.Direct AMP-activated protein kinase activators: a review of evidence from the patent literature.Activators of AMPK: not just for type II diabetes.AMPK: energy sensor and survival mechanism in the ischemic heart.Hearts lacking plasma membrane KATP channels display changes in basal aerobic metabolic substrate preference and AMPK activity.Heat shock protein 70 protects cardiomyocytes through suppressing SUMOylation and nucleus translocation of phosphorylated eukaryotic elongation factor 2 during myocardial ischemia and reperfusion.Effect of AMP-activated protein kinase activation on cardiac fibroblast proliferation induced by coxsackievirus B3.AMPK in Cardiovascular Diseases.Targeting the energy guardian AMPK: another avenue for treating cardiomyopathy?Simulated microgravity increases myocardial susceptibility to ischemia-reperfusion injury via a deficiency of AMP-activated protein kinase.Cardioprotection by acetylcholine: a novel mechanism via mitochondrial biogenesis and function involving the PGC-1α pathway.Metabolic remodelling in hypertrophied and failing myocardium: a review.Sestrin2 prevents age-related intolerance to ischemia and reperfusion injury by modulating substrate metabolism.Hypoxia decreases creatine uptake in cardiomyocytes, while creatine supplementation enhances HIF activation.Effect of Selenium Deficiency on Phosphorylation of the AMPK Pathway in Rats.Autophagy is involved in the cardioprotection effect of remote limb ischemic postconditioning on myocardial ischemia/reperfusion injury in normal mice, but not diabetic miceMitochondrial ROS deficiency and diabetic complications: AMP[K]-lifying the adaptation to hyperglycemia.LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation.The Protective Effects of Areca catechu Extract on Cognition and Social Interaction Deficits in a Cuprizone-Induced Demyelination Model.Control of Glycolytic Flux by AMP-Activated Protein Kinase in Tumor Cells Adapted to Low pHBiochemical targets of drugs mitigating oxidative stress via redox-independent mechanisms.
P2860
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P2860
A small molecule AMPK activator protects the heart against ischemia-reperfusion injury.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
A small molecule AMPK activator protects the heart against ischemia-reperfusion injury.
@en
A small molecule AMPK activator protects the heart against ischemia-reperfusion injury.
@nl
type
label
A small molecule AMPK activator protects the heart against ischemia-reperfusion injury.
@en
A small molecule AMPK activator protects the heart against ischemia-reperfusion injury.
@nl
prefLabel
A small molecule AMPK activator protects the heart against ischemia-reperfusion injury.
@en
A small molecule AMPK activator protects the heart against ischemia-reperfusion injury.
@nl
P2093
P2860
P1476
A small molecule AMPK activator protects the heart against ischemia-reperfusion injury
@en
P2093
Agnes S Kim
Kei Sakamoto
Kwame Atsina
Lawrence H Young
Tracy M Wright
P2860
P356
10.1016/J.YJMCC.2011.03.003
P577
2011-03-29T00:00:00Z