The DNA binding domain of p53 is sufficient to trigger a potent apoptotic response at the mitochondria.
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Delivery of a monomeric p53 subdomain with mitochondrial targeting signals from pro-apoptotic Bak or Bax.Re-engineered p53 activates apoptosis in vivo and causes primary tumor regression in a dominant negative breast cancer xenograft model.A conserved mechanism for binding of p53 DNA-binding domain and anti-apoptotic Bcl-2 family proteins.The physical interaction of p53 and plakoglobin is necessary for their synergistic inhibition of migration and invasion.A novel tumor suppressor gene in basal cell carcinoma: inhibition of growth factor-2.ArhGAP30 promotes p53 acetylation and function in colorectal cancer.
P2860
The DNA binding domain of p53 is sufficient to trigger a potent apoptotic response at the mitochondria.
description
2013 nî lūn-bûn
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2013年の論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年论文
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2013年论文
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name
The DNA binding domain of p53 ...... response at the mitochondria.
@en
The DNA binding domain of p53 ...... response at the mitochondria.
@nl
type
label
The DNA binding domain of p53 ...... response at the mitochondria.
@en
The DNA binding domain of p53 ...... response at the mitochondria.
@nl
prefLabel
The DNA binding domain of p53 ...... response at the mitochondria.
@en
The DNA binding domain of p53 ...... response at the mitochondria.
@nl
P2093
P356
P1476
The DNA binding domain of p53 ...... response at the mitochondria.
@en
P2093
Abood Okal
Carol S Lim
Karina J Matissek
Mohanad Mossalam
P304
P356
10.1021/MP400380S
P407
P577
2013-09-06T00:00:00Z