LSD1-mediated epigenetic modification contributes to proliferation and metastasis of colon cancer.
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Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targetingKDM1 class flavin-dependent protein lysine demethylasesVitamin D and the epigenome.Melatonin exerts anti-oral cancer effect via suppressing LSD1 in patient-derived tumor xenograft models.Silencing of the DNA mismatch repair gene MLH1 induced by hypoxic stress in a pathway dependent on the histone demethylase LSD1Microenvironmental Influences on Metastasis Suppressor Expression and Function during a Metastatic Cell's Journey.Calcium-sensing receptor silencing in colorectal cancer is associated with promoter hypermethylation and loss of acetylation on histone 3.Histone Demethylases in Colon Cancer.Expression of Lysine-specific demethylase 1 in human epithelial ovarian cancer.Successful strategies in the discovery of small-molecule epigenetic modulators with anticancer potential.Lysine-specific demethylase 1 mediates epidermal growth factor signaling to promote cell migration in ovarian cancer cells.Preclinical activity of combined HDAC and KDM1A inhibition in glioblastoma.Long non-coding RNA UCA1 induces non-T790M acquired resistance to EGFR-TKIs by activating the AKT/mTOR pathway in EGFR-mutant non-small cell lung cancer.Circadian clocks, epigenetics, and cancer.MicroRNA-506 suppresses tumor proliferation and metastasis in colon cancer by directly targeting the oncogene EZH2Extracellular matrix gene expression profiling using microfluidics for colorectal carcinoma stratification.High expression of WISP1 in colon cancer is associated with apoptosis, invasion and poor prognosis.Long non-coding RNA BC087858 induces non-T790M mutation acquired resistance to EGFR-TKIs by activating PI3K/AKT and MEK/ERK pathways and EMT in non-small-cell lung cancer.Identification of downstream metastasis-associated target genes regulated by LSD1 in colon cancer cells.Effects of deranged metabolism on epigenetic changes in cancer.Regulation of breast cancer stem cell features.KDM1 histone lysine demethylases as targets for treatments of oncological and neurodegenerative disease.Advances toward LSD1 inhibitors for cancer therapy.Novel KDM1A inhibitors induce differentiation and apoptosis of glioma stem cells via unfolded protein response pathway.The EMT regulator ZEB2 is a novel dependency of human and murine acute myeloid leukemia.Upregulated SMYD3 promotes bladder cancer progression by targeting BCLAF1 and activating autophagy.TCPs: privileged scaffolds for identifying potent LSD1 inhibitors for cancer therapy.Synthesis, LSD1 Inhibitory Activity, and LSD1 Binding Model of Optically Pure Lysine-PCPA Conjugates.Orthotopic non-metastatic and metastatic oral cancer mouse models.High expression of the histone demethylase LSD1 associates with cancer cell proliferation and unfavorable prognosis in tongue cancer.Histone Lysine Demethylase Inhibitors.Targeting histone methylation for colorectal cancerA comprehensive review of lysine-specific demethylase 1 and its roles in cancer.Phosphorylation of LSD1 at Ser112 is crucial for its function in induction of EMT and metastasis in breast cancer.Correlations of insulin-like growth factor I and insulin-like growth factor I receptor with the clinicopathological features and prognosis of patients with colon cancer.Silencing of LSD1 gene modulates histone methylation and acetylation and induces the apoptosis of JeKo-1 and MOLT-4 cells.The pseudogene derived from long non-coding RNA DUXAP10 promotes colorectal cancer cell growth through epigenetically silencing of p21 and PTEN.GATA2 regulates GATA1 expression through LSD1-mediated histone modification.Lysine-specific demethylase 1 (LSD1) destabilizes p62 and inhibits autophagy in gynecologic malignancies.LSD1, a double-edged sword, confers dynamic chromatin regulation but commonly promotes aberrant cell growth.
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LSD1-mediated epigenetic modification contributes to proliferation and metastasis of colon cancer.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
LSD1-mediated epigenetic modif ...... nd metastasis of colon cancer.
@en
LSD1-mediated epigenetic modif ...... nd metastasis of colon cancer.
@nl
type
label
LSD1-mediated epigenetic modif ...... nd metastasis of colon cancer.
@en
LSD1-mediated epigenetic modif ...... nd metastasis of colon cancer.
@nl
prefLabel
LSD1-mediated epigenetic modif ...... nd metastasis of colon cancer.
@en
LSD1-mediated epigenetic modif ...... nd metastasis of colon cancer.
@nl
P2093
P2860
P356
P1476
LSD1-mediated epigenetic modif ...... nd metastasis of colon cancer.
@en
P2093
P2860
P2888
P304
P356
10.1038/BJC.2013.364
P407
P577
2013-07-30T00:00:00Z
P5875
P6179
1011061134