Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts.
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Establishment of a Predictive In Vitro Assay for Assessment of the Hepatotoxic Potential of Oligonucleotide DrugsRibonuclease H1-dependent hepatotoxicity caused by locked nucleic acid-modified gapmer antisense oligonucleotidesFrom the Cover: The Minipig is a Suitable Non-Rodent Model in the Safety Assessment of Single Stranded Oligonucleotides.Targeting DMPK with Antisense Oligonucleotide Improves Muscle Strength in Myotonic Dystrophy Type 1 MiceLNA/DNA mixmer-based antisense oligonucleotides correct alternative splicing of the SMN2 gene and restore SMN protein expression in type 1 SMA fibroblastsDevelopment of Antisense Drugs for Dyslipidemia.Inhibition of EGF Uptake by Nephrotoxic Antisense Drugs In Vitro and Implications for Preclinical Safety Profiling.Managing the sequence-specificity of antisense oligonucleotides in drug discovery.The chemical evolution of oligonucleotide therapies of clinical utility.Strategies for In Vivo Screening and Mitigation of Hepatotoxicity Associated with Antisense Drugs.Gapmer Antisense Oligonucleotides Suppress the Mutant Allele of COL6A3 and Restore Functional Protein in Ullrich Muscular Dystrophy.Locked Nucleic Acid Gapmers and Conjugates Potently Silence ADAM33, an Asthma-Associated Metalloprotease with Nuclear-Localized mRNAMolecular Mechanisms of Antisense Oligonucleotides.Assessing single-stranded oligonucleotide drug-induced effects in vitro reveals key risk factors for thrombocytopenia.A Sensitive In Vitro Approach to Assess the Hybridization-Dependent Toxic Potential of High Affinity Gapmer Oligonucleotides.The intratracheal administration of locked nucleic acid containing antisense oligonucleotides induced gene silencing and an immune-stimulatory effect in the murine lung.BNANC Gapmers Revert Splicing and Reduce RNA Foci with Low Toxicity in Myotonic Dystrophy Cells.Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs.Acute hepatotoxicity of 2' fluoro-modified 5-10-5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins.Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity.Modulation of blood-brain barrier function by a heteroduplex oligonucleotide in vivo.Identifying and avoiding off-target effects of RNase H-dependent antisense oligonucleotides in mice.Hydrogel-Assisted Antisense LNA Gapmer Delivery for In Situ Gene Silencing in Spinal Cord Injury.Circular RNAs as Therapeutic Agents and TargetsApplication of 2'-O-(2-N-Methylcarbamoylethyl) Nucleotides in RNase H-Dependent Antisense Oligonucleotides
P2860
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P2860
Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Hepatotoxicity of high affinit ...... ery long pre-mRNA transcripts.
@en
Hepatotoxicity of high affinit ...... ery long pre-mRNA transcripts.
@nl
type
label
Hepatotoxicity of high affinit ...... ery long pre-mRNA transcripts.
@en
Hepatotoxicity of high affinit ...... ery long pre-mRNA transcripts.
@nl
prefLabel
Hepatotoxicity of high affinit ...... ery long pre-mRNA transcripts.
@en
Hepatotoxicity of high affinit ...... ery long pre-mRNA transcripts.
@nl
P2093
P2860
P356
P1476
Hepatotoxicity of high affinit ...... ery long pre-mRNA transcripts.
@en
P2093
C Frank Bennett
Christopher E Hart
Eric E Swayze
Husam Younis
Huynh-Hoa Bui
Jill Hsiao
Mahyar Sabripour
P2860
P304
P356
10.1093/NAR/GKV1210
P407
P577
2015-11-08T00:00:00Z