Anti-Notch treatment prevents multiple myeloma cells localization to the bone marrow via the chemokine system CXCR4/SDF-1. - Wikidata - wikimedia - TriplyDB

Anti-Notch treatment prevents multiple myeloma cells localization to the bone marrow via the chemokine system CXCR4/SDF-1.

Anti-Notch treatment prevents multiple myeloma cells localization to the bone marrow via the chemokine system CXCR4/SDF-1.

http://www.wikidata.org/entity/Q39203918

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Multiple myeloma cancer stem cells Notch signaling deregulation in multiple myeloma: A rational molecular target Heparin-binding epidermal growth factor-like growth factor/diphtheria toxin receptor in normal and neoplastic hematopoiesis Notch pathway inhibition controls myeloma bone disease in the murine MOPC315.BM model.Multiple myeloma mesenchymal stromal cells: Contribution to myeloma bone disease and therapeutics CD138-negative myeloma cells regulate mechanical properties of bone marrow stromal cells through SDF-1/CXCR4/AKT signaling pathway In vivo molecular imaging of chemokine receptor CXCR4 expression in patients with advanced multiple myeloma.CXCL12 Signaling Is Essential for Maturation of the Ventricular Coronary Endothelial Plexus and Establishment of Functional Coronary Circulation Pro-Inflammatory Cytokine IL-1β Up-Regulates CXC Chemokine Receptor 4 via Notch and ERK Signaling Pathways in Tongue Squamous Cell Carcinoma.Anti-myeloma effect of pharmacological inhibition of Notch/gamma-secretase with RO4929097 is mediated by modulation of tumor microenvironment.Systemic therapy with oncolytic myxoma virus cures established residual multiple myeloma in mice.Interplay between CCR7 and Notch1 axes promotes stemness in MMTV-PyMT mammary cancer cells Multiple myeloma-derived Jagged ligands increases autocrine and paracrine interleukin-6 expression in bone marrow niche.A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysis.Fact or fiction--identifying the elusive multiple myeloma stem cell.Concise review: Defining and targeting myeloma stem cell-like cells.The role of notch signaling in bone marrow niche.Pleiotropic roles of Notch signaling in normal, malignant, and developmental hematopoiesis in the human.The osteoblastic niche in the context of multiple myeloma.Targeting Tumor Initiating Cells through Inhibition of Cancer Testis Antigens and Notch Signaling: A Hypothesis.Insights into the mechanism of CXCL12-mediated signaling in trophoblast functions and placental angiogenesis.Notch signaling in cerebrovascular diseases (Review)Notch signaling drives multiple myeloma induced osteoclastogenesis.The hypoxia signalling pathway in haematological malignancies.Multiple myeloma cells modify VEGF/IL-6 levels and osteogenic potential of bone marrow stromal cells via Notch/miR-223.The γ-secretase inhibitors enhance the anti-leukemic activity of ibrutinib in B-CLL cells.Changes in circulating endothelial progenitor cells predict responses of multiple myeloma patients to treatment with bortezomib and dexamethasone.Cancer testis antigen Sperm Protein 17 as a new target for triple negative breast cancer immunotherapy.Pathogenesis of bone disease in multiple myeloma: from bench to bedside.High expression of C-X-C chemokine receptor 4 and Notch1 is predictive of lymphovascular invasion and poor prognosis in lung adenocarcinoma.PI3K/AKT signaling inhibits NOTCH1 lysosome-mediated degradation.Cancer Cells Exploit Notch Signaling to Redefine a Supportive Cytokine Milieu

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Anti-Notch treatment prevents multiple myeloma cells localization to the bone marrow via the chemokine system CXCR4/SDF-1.

http://www.wikidata.org/entity/Q39203918

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Anti-Notch treatment prevents ...... chemokine system CXCR4/SDF-1.

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Anti-Notch treatment prevents ...... chemokine system CXCR4/SDF-1.

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P2860

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.

Direct inhibition of the NOTCH transcription factor complex

Skeletrophin, a novel ubiquitin ligase to the intracellular region of Jagged-2, is aberrantly expressed in multiple myeloma

Galectin-3C inhibits tumor growth and increases the anticancer activity of bortezomib in a murine model of human multiple myeloma

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy.

Notch and the immune system.

Advances in the understanding of myeloma bone disease and tumour growth.

Tracking human multiple myeloma xenografts in NOD-Rag-1/IL-2 receptor gamma chain-null mice with the novel biomarker AKAP-4

Overexpression of the NOTCH ligand JAG2 in malignant plasma cells from multiple myeloma patients and cell lines.

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10.1038/LEU.2013.27

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7

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27

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