Genetically altering the thermodynamics and kinetics of hepatitis B virus capsid assembly has profound effects on virus replication in cell culture.
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Hepatitis B virus therapy: What's the future holding for us?Assembly-Directed Antivirals Differentially Bind Quasiequivalent Pockets to Modify Hepatitis B Virus Capsid Tertiary and Quaternary StructureEncapsidated hepatitis B virus reverse transcriptase is poised on an ordered RNA latticeAlteration of Mature Nucleocapsid and Enhancement of Covalently Closed Circular DNA Formation by Hepatitis B Virus Core Mutants Defective in Complete-Virion Formation.A novel pyridazinone derivative inhibits hepatitis B virus replication by inducing genome-free capsid formationHepatitis B Virus Capsids Have Diverse Structural Responses to Small-Molecule Ligands Bound to the Heteroaryldihydropyrimidine PocketHepatitis B Virus Polymerase Localizes to the Mitochondria, and Its Terminal Protein Domain Contains the Mitochondrial Targeting Signal.Allosteric modulation of protein oligomerization: an emerging approach to drug design.Core protein: A pleiotropic keystone in the HBV lifecycle.New paradigms in hepatitis B management: only diamonds are forever.Assembly and Release of Hepatitis B Virus.Quantitative computational models of molecular self-assembly in systems biology.Influences on viral replication and sensitivity to GLS4, a HAP compound, of naturally occurring T109/V124 mutations in hepatitis B virus core protein.Discovery and Mechanistic Study of Benzamide Derivatives That Modulate Hepatitis B Virus Capsid Assembly.Cell-Free Hepatitis B Virus Capsid Assembly Dependent on the Core Protein C-Terminal Domain and Regulated by PhosphorylationStructurally similar woodchuck and human hepadnavirus core proteins have distinctly different temperature dependences of assembly.The interface between hepatitis B virus capsid proteins affects self-assembly, pregenomic RNA packaging, and reverse transcription.The Structural Biology of Hepatitis B Virus: Form and Function.Transmission genetics of drug-resistant hepatitis C virus.Hepatitis B virus core protein dephosphorylation occurs during pregenomic RNA encapsidation.Assembly Properties of Hepatitis B Virus Core Protein Mutants Correlate with Their Resistance to Assembly-Directed Antivirals
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P2860
Genetically altering the thermodynamics and kinetics of hepatitis B virus capsid assembly has profound effects on virus replication in cell culture.
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Genetically altering the therm ...... s replication in cell culture.
@en
Genetically altering the therm ...... s replication in cell culture.
@nl
type
label
Genetically altering the therm ...... s replication in cell culture.
@en
Genetically altering the therm ...... s replication in cell culture.
@nl
prefLabel
Genetically altering the therm ...... s replication in cell culture.
@en
Genetically altering the therm ...... s replication in cell culture.
@nl
P2093
P2860
P356
P1433
P1476
Genetically altering the therm ...... s replication in cell culture.
@en
P2093
Daniel D Loeb
Megan L Maguire
Zhenning Tan
P2860
P304
P356
10.1128/JVI.03014-12
P407
P577
2013-01-02T00:00:00Z