An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1.
about
A KCNQ1 mutation contributes to the concealed type 1 long QT phenotype by limiting the Kv7.1 channel conformational changes associated with protein kinase A phosphorylationKCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targetingDrug-induced Inhibition and Trafficking Disruption of ion Channels: Pathogenesis of QT Abnormalities and Drug-induced Fatal Arrhythmias.Fatty acid analogue N-arachidonoyl taurine restores function of IKs channels with diverse long QT mutations.Quantitative analysis of the Ca2+ -dependent regulation of delayed rectifier K+ current IKs in rabbit ventricular myocytes.
P2860
An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1.
description
2012 nî lūn-bûn
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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name
An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1.
@en
An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1.
@nl
type
label
An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1.
@en
An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1.
@nl
prefLabel
An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1.
@en
An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1.
@nl
P2093
P2860
P356
P1476
An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1.
@en
P2093
Brenda F Leake
Charles R Sanders
Dan M Roden
Jarrod A Smith
P2860
P304
P356
10.1124/MOL.112.081513
P50
P577
2012-11-28T00:00:00Z