Protein phosphatase 2A (PP2A)-specific ubiquitin ligase MID1 is a sequence-dependent regulator of translation efficiency controlling 3-phosphoinositide-dependent protein kinase-1 (PDPK-1).
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Mechanisms of RNA-induced toxicity in CAG repeat disordersThe anti-diabetic drug metformin reduces BACE1 protein level by interfering with the MID1 complexRole of anti-diabetic drugs as therapeutic agents in Alzheimer's diseaseMID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 domain disrupt polyubiquitination of alpha4 but not of PP2Ac.The MID1 E3 ligase catalyzes the polyubiquitination of Alpha4 (α4), a regulatory subunit of protein phosphatase 2A (PP2A): novel insights into MID1-mediated regulation of PP2A.Allele-selective suppression of mutant genes in polyglutamine diseases.A hormone-dependent feedback-loop controls androgen receptor levels by limiting MID1, a novel translation enhancer and promoter of oncogenic signalingRegulation of mRNA Translation by MID1: A Common Mechanism of Expanded CAG Repeat RNAs.Metformin anti-tumor effect via disruption of the MID1 translational regulator complex and AR downregulation in prostate cancer cells.Reduced Mid1 Expression and Delayed Neuromotor Development in daDREAM Transgenic Mice.MicroRNAs miR-19, miR-340, miR-374 and miR-542 regulate MID1 protein expression.Two Novel Pathogenic MID1 Variants and Genotype-Phenotype Correlation Reanalysis in X-Linked Opitz G/BBB Syndrome.Inhibition of the MID1 protein complex: a novel approach targeting APP protein synthesis.Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1-PP2A protein complex.
P2860
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P2860
Protein phosphatase 2A (PP2A)-specific ubiquitin ligase MID1 is a sequence-dependent regulator of translation efficiency controlling 3-phosphoinositide-dependent protein kinase-1 (PDPK-1).
description
2011 nî lūn-bûn
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2011年の論文
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2011年学术文章
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2011年学术文章
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name
Protein phosphatase 2A (PP2A)- ...... ent protein kinase-1 (PDPK-1).
@en
Protein phosphatase 2A
@nl
type
label
Protein phosphatase 2A (PP2A)- ...... ent protein kinase-1 (PDPK-1).
@en
Protein phosphatase 2A
@nl
prefLabel
Protein phosphatase 2A (PP2A)- ...... ent protein kinase-1 (PDPK-1).
@en
Protein phosphatase 2A
@nl
P2093
P2860
P356
P1476
Protein phosphatase 2A (PP2A)- ...... ent protein kinase-1 (PDPK-1).
@en
P2093
Andrea Köhler
Antonios I Karagiannidis
Beatriz Aranda-Orgillés
Changwei Chen
David Lilley
Désirée Rutschow
Rainer Schneider
Raphael Zeller
Stefan Roepcke
Susann Schweiger
P2860
P304
39945-39957
P356
10.1074/JBC.M111.224451
P407
P577
2011-09-19T00:00:00Z