Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity.
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Redox Modulating NRF2: A Potential Mediator of Cancer Stem Cell ResistanceComparative analysis of NRF2-responsive gene expression in AcPC-1 pancreatic cancer cell lineMetallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosisParadoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health ImplicationsCytoprotection "gone astray": Nrf2 and its role in cancerInhibition of NRF2 by PIK-75 augments sensitivity of pancreatic cancer cells to gemcitabineKaposi's sarcoma-associated herpesvirus induces Nrf2 during de novo infection of endothelial cells to create a microenvironment conducive to infectionActivation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cellsNrf2 is the key to chemotherapy resistance in MCF7 breast cancer cells under hypoxiaThe Brassica-derived phytochemical indolo[3,2-b]carbazole protects against oxidative DNA damage by aryl hydrocarbon receptor activation.Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2.Low nanomolar concentrations of Cucurbitacin-I induces G2/M phase arrest and apoptosis by perturbing redox homeostasis in gastric cancer cells in vitro and in vivoRole of NF-E2 related factor 2 (Nrf2) on chemotherapy resistance in acute myeloid leukemia (AML) and the effect of pharmacological inhibition of Nrf2Bioactive micronutrients in coffee: recent analytical approaches for characterization and quantification.Catalase overexpression prevents nuclear factor erythroid 2-related factor 2 stimulation of renal angiotensinogen gene expression, hypertension, and kidney injury in diabetic mice.Targeting nrf2 signaling to combat chemoresistance.The role of the catecholic and the electrophilic moieties of caffeic acid in Nrf2/Keap1 pathway activation in ovarian carcinoma cell lines.Apurinic/apyrimidinic endonuclease/redox factor-1 (APE1/Ref-1) redox function negatively regulates NRF2.Benefits and risks of the hormetic effects of dietary isothiocyanates on cancer prevention.The Crosstalk between Nrf2 and TGF-β1 in the Epithelial-Mesenchymal Transition of Pancreatic Duct Epithelial Cells.Functional Role of NRF2 in Cervical Carcinogenesis.Gene expression profiling of ovarian carcinomas and prognostic analysis of outcome.An Integrated Molecular Analysis of Lung Adenocarcinomas Identifies Potential Therapeutic Targets among TTF1-Negative Tumors, Including DNA Repair Proteins and Nrf2.The anti-oxidative transcription factor Nuclear factor E2 related factor-2 (Nrf2) counteracts TGF-β1 mediated growth inhibition of pancreatic ductal epithelial cells -Nrf2 as determinant of pro-tumorigenic functions of TGF-β1.A clinical drug library screen identifies clobetasol propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancer.Oxidative stress contributes to the tamoxifen-induced killing of breast cancer cells: implications for tamoxifen therapy and resistance.Brusatol Enhances the Radiosensitivity of A549 Cells by Promoting ROS Production and Enhancing DNA DamageOverview on how oncogenic Kras promotes pancreatic carcinogenesis by inducing low intracellular ROS levels.The timing of caffeic acid treatment with cisplatin determines sensitization or resistance of ovarian carcinoma cell lines.Noncanonical SQSTM1/p62-Nrf2 pathway activation mediates proteasome inhibitor resistance in multiple myeloma cells via redox, metabolic and translational reprogramming.Discovery of a novel Nrf2 inhibitor that induces apoptosis of human acute myeloid leukemia cellsInhibition of cancer antioxidant defense by natural compounds.Natural product-derived pharmacological modulators of Nrf2/ARE pathway for chronic diseases.Coffee: biochemistry and potential impact on health.Role of the Nrf2 signaling system in health and disease.Genomic and Epigenomic Aberrations in Esophageal Squamous Cell Carcinoma and Implications for Patients.Nrf2: a potential therapeutic target for naturally occurring anticancer drugs?Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters.c-Rel is a critical mediator of NF-κB-dependent TRAIL resistance of pancreatic cancer cells.Modulation of nuclear factor E2-related factor-2 (Nrf2) activation by the stress response gene immediate early response-3 (IER3) in colonic epithelial cells: a novel mechanism of cellular adaption to inflammatory stress
P2860
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P2860
Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Inhibition of the Nrf2 transcr ...... ssion and proteasome activity.
@en
Inhibition of the Nrf2 transcr ...... ssion and proteasome activity.
@nl
type
label
Inhibition of the Nrf2 transcr ...... ssion and proteasome activity.
@en
Inhibition of the Nrf2 transcr ...... ssion and proteasome activity.
@nl
prefLabel
Inhibition of the Nrf2 transcr ...... ssion and proteasome activity.
@en
Inhibition of the Nrf2 transcr ...... ssion and proteasome activity.
@nl
P2093
P2860
P356
P1433
P1476
Inhibition of the Nrf2 transcr ...... ssion and proteasome activity.
@en
P2093
C Geismann
M Grossmann
S Schreiber
P2860
P2888
P304
P356
10.1038/ONC.2012.493
P407
P577
2012-10-29T00:00:00Z