Smad4-dependent TGF-beta signaling suppresses RON receptor tyrosine kinase-dependent motility and invasion of pancreatic cancer cells.
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RhoT1 and Smad4 are correlated with lymph node metastasis and overall survival in pancreatic cancerRoles of c-Met and RON kinases in tumor progression and their potential as therapeutic targetsRon knockdown and Ron monoclonal antibody IMC-RON8 sensitize pancreatic cancer to histone deacetylase inhibitors (HDACi)The involvement of insulin-like growth factor 2 binding protein 3 (IMP3) in pancreatic cancer cell migration, invasion, and adhesionEffects of PTCs on nonsense-mediated mRNA decay are dependent on PTC locationmiR‑196a‑5p modulates gastric cancer stem cell characteristics by targeting Smad4.Expression of oncogenic K-ras and loss of Smad4 cooperate to induce the expression of EGFR and to promote invasion of immortalized human pancreas ductal cells.Oncogenic K-Ras and loss of Smad4 mediate invasion by activating an EGFR/NF-κB Axis that induces expression of MMP9 and uPA in human pancreas progenitor cells.Loss of canonical Smad4 signaling promotes KRAS driven malignant transformation of human pancreatic duct epithelial cells and metastasis.RON (MST1R) is a novel prognostic marker and therapeutic target for gastroesophageal adenocarcinoma.A miRNA signature of chemoresistant mesenchymal phenotype identifies novel molecular targets associated with advanced pancreatic cancer.Deploying mouse models of pancreatic cancer for chemoprevention studiesInsights Into SMAD4 Loss in Pancreatic Cancer From Inducible Restoration of TGF-β Signaling.Ron tyrosine kinase receptor synergises with EGFR to confer adverse features in head and neck squamous cell carcinoma.Crosstalk between RON and androgen receptor signaling in the development of castration resistant prostate cancerKnockdown of RON receptor kinase delays but does not prevent tumor progression while enhancing HGF/MET signaling in pancreatic cancer cell lines.Prognostic value of loss of heterozygosity and sub-cellular localization of SMAD4 varies with tumor stage in colorectal cancer.Molecular biology of pancreatic ductal adenocarcinoma progression: aberrant activation of developmental pathways.SMAD4 and its role in pancreatic cancer.Cadherin-11 Is a Cell Surface Marker Up-Regulated in Activated Pancreatic Stellate Cells and Is Involved in Pancreatic Cancer Cell Migration.Transforming growth factor-β/SMAD Target gene SKIL is negatively regulated by the transcriptional cofactor complex SNON-SMAD4.The Role of Platelet-Derived ADP and ATP in Promoting Pancreatic Cancer Cell Survival and Gemcitabine Resistance.Effects and mechanism of irbesartan on tubulointerstitial fibrosis in 5/6 nephrectomized rats.Function of the c-Met receptor tyrosine kinase in carcinogenesis and associated therapeutic opportunities.
P2860
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P2860
Smad4-dependent TGF-beta signaling suppresses RON receptor tyrosine kinase-dependent motility and invasion of pancreatic cancer cells.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Smad4-dependent TGF-beta signa ...... on of pancreatic cancer cells.
@en
Smad4-dependent TGF-beta signa ...... on of pancreatic cancer cells.
@nl
type
label
Smad4-dependent TGF-beta signa ...... on of pancreatic cancer cells.
@en
Smad4-dependent TGF-beta signa ...... on of pancreatic cancer cells.
@nl
prefLabel
Smad4-dependent TGF-beta signa ...... on of pancreatic cancer cells.
@en
Smad4-dependent TGF-beta signa ...... on of pancreatic cancer cells.
@nl
P2093
P2860
P356
P1476
Smad4-dependent TGF-beta signa ...... on of pancreatic cancer cells.
@en
P2093
Amalraj Thangasamy
James W Freeman
Michael Brattain
Shujie Zhao
Sudhakar Ammanamanchi
P2860
P304
11293-11301
P356
10.1074/JBC.M800154200
P407
P577
2008-02-29T00:00:00Z