Anti-CD40 monoclonal antibody synergizes with CTLA4-Ig in promoting long-term graft survival in murine models of transplantation. - Wikidata - wikimedia - TriplyDB

Anti-CD40 monoclonal antibody synergizes with CTLA4-Ig in promoting long-term graft survival in murine models of transplantation.

Anti-CD40 monoclonal antibody synergizes with CTLA4-Ig in promoting long-term graft survival in murine models of transplantation.

http://www.wikidata.org/entity/Q39265882

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Tolerogenic Dendritic Cells on Transplantation: Immunotherapy Based on Second Signal Blockage Update on CD40 and CD154 blockade in transplant models Treg-therapy allows mixed chimerism and transplantation tolerance without cytoreductive conditioning Promoting long-term survival of insulin-producing cell grafts that differentiate from adipose tissue-derived stem cells to cure type 1 diabetes Costimulatory pathways in transplantation.GVHD after haploidentical transplantation: a novel, MHC-defined rhesus macaque model identifies CD28- CD8+ T cells as a reservoir of breakthrough T-cell proliferation during costimulation blockade and sirolimus-based immunosuppression Soluble co-signaling molecules predict long-term graft outcome in kidney-transplanted patients CTLA4-Ig prevents alloantibody production and BMT rejection in response to platelet transfusions in mice.An anti-CD154 domain antibody prolongs graft survival and induces Foxp3(+) iTreg in the absence and presence of CTLA-4 Ig.Signal one and two blockade are both critical for non-myeloablative murine HSCT across a major histocompatibility complex barrier.CD40 blockade combines with CTLA4Ig and sirolimus to produce mixed chimerism in an MHC-defined rhesus macaque transplant model.Nondepleting anti-CD40-based therapy prolongs allograft survival in nonhuman primates.T-cell activation and transplantation tolerance.CTLA4Ig prevents alloantibody formation following nonhuman primate islet transplantation using the CD40-specific antibody 3A8 Loss of DRAK2 signaling enhances allogeneic transplant survival by limiting effector and memory T cell responses.CD40/CD154 blockade inhibits dendritic cell expression of inflammatory cytokines but not costimulatory molecules CD40-specific costimulation blockade enhances neonatal porcine islet survival in nonhuman primates.Combined costimulatory and leukocyte functional antigen-1 blockade prevents transplant rejection mediated by heterologous immune memory alloresponses Inhibition of CD8+ T cell-derived CD40 signals is necessary but not sufficient for Foxp3+ induced regulatory T cell generation in vivo.Belatacept: a new era of immunosuppression?Costimulation blockade: current perspectives and implications for therapy.Targeting co-stimulatory pathways: transplantation and autoimmunity.Costimulatory pathways in kidney transplantation: pathogenetic role, clinical significance and new therapeutic opportunities.Taming inflammation by targeting cytokine signaling: new perspectives in the induction of transplantation tolerance.Hematopoietic stem cell infusion/transplantation for induction of allograft tolerance.IL-7 receptor blockade following T cell depletion promotes long-term allograft survival.T Cell Cosignaling Molecules in Transplantation.Advances in targeting co-inhibitory and co-stimulatory pathways in transplantation settings: the Yin to the Yang of cancer immunotherapy.Attrition of memory CD8 T cells during sepsis requires LFA-1 Synergic silencing of costimulatory molecules prevents cardiac allograft rejection.Distinct strategies are required to suppress antigen-specific responses to genetically modified keratinocytes and fibroblasts.CXCR4 blockade decreases CD4+ T cell exhaustion and improves survival in a murine model of polymicrobial sepsis.Pre-clinical results in pig-to-non-human primate islet xenotransplantation using anti-CD40 antibody (2C10R4)-based immunosuppression.Soluble CD40 ligand (sCD40L) provides a new delivery system for targeted treatment: sCD40L-caspase 3 chimeric protein for treating B-cell malignancies.Fc-Silent Anti-CD154 Domain Antibody Effectively Prevents Nonhuman Primate Renal Allograft Rejection.Rapamycin and CTLA4Ig synergize to induce stable mixed chimerism without the need for CD40 blockade.T Cell Repertoire Maturation Induced by Persistent and Latent Viral Infection Is Insufficient to Induce Costimulation Blockade Resistant Organ Allograft Rejection in Mice.

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P2860

Anti-CD40 monoclonal antibody synergizes with CTLA4-Ig in promoting long-term graft survival in murine models of transplantation.

http://www.wikidata.org/entity/Q39265882

description

2009 nî lūn-bûn

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年學術文章

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2009年學術文章

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2009年學術文章

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name

Anti-CD40 monoclonal antibody ...... ine models of transplantation.

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Anti-CD40 monoclonal antibody ...... ine models of transplantation.

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Anti-CD40 monoclonal antibody ...... ine models of transplantation.

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JIMMUNOL.0900339

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Journal of Immunology

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Anti-CD40 monoclonal antibody ...... ine models of transplantation.

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P2093

Christian P Larsen

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Christopher R Gilson

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Diane Hollenbaugh

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Mandy L Ford

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Shivaprakash Gangappa

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Thomas C Pearson

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Zvonimir Milas

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P2860

CD40 AND CD154 IN CELL-MEDIATED IMMUNITY

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation

Differential regulation of cell survival by CD40

Fcgamma receptors: old friends and new family members

Regulation of the lifespan in dendritic cell subsets

The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation

IgG Fc receptors

Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412

Asialo GM1(+) CD8(+) T cells play a critical role in costimulation blockade-resistant allograft rejection.

Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation.

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1625-1635

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10.4049/JIMMUNOL.0900339

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19592649

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2828346

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