Lipid-mediated folding/unfolding of phospholamban as a regulatory mechanism for the sarcoplasmic reticulum Ca2+-ATPase
about
Structural topology of phospholamban pentamer in lipid bilayers by a hybrid solution and solid-state NMR methodStructures of the Excited States of Phospholamban and Shifts in Their Populations upon PhosphorylationStructural Dynamics and Topology of Phosphorylated Phospholamban Homopentamer Reveal Its Role in the Regulation of Calcium TransportCa(2+) ATPase Conformational Transitions in Lipid Bilayers Mapped by Site-directed Ethylation and Solid-State NMRAtomic-level characterization of the activation mechanism of SERCA by calciumProbing ground and excited states of phospholamban in model and native lipid membranes by magic angle spinning NMR spectroscopy.Structural dynamics and conformational equilibria of SERCA regulatory proteins in membranes by solid-state NMR restrained simulations.Comparison of the structure and function of phospholamban and the arginine-14 deficient mutant associated with dilated cardiomyopathy.High-throughput FRET assay yields allosteric SERCA activatorsPhospholamban phosphorylation, mutation, and structural dynamics: a biophysical approach to understanding and treating cardiomyopathy.Mechanotransduction Mechanisms for Intraventricular Diastolic Vortex Forces and Myocardial Deformations: Part 2.Activating and deactivating roles of lipid bilayers on the Ca(2+)-ATPase/phospholamban complexTuning the structural coupling between the transmembrane and cytoplasmic domains of phospholamban to control sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) function.Heteronuclear Adiabatic Relaxation Dispersion (HARD) for quantitative analysis of conformational dynamics in proteins.Regulated unfolding of proteins in signalingAllosteric regulation of SERCA by phosphorylation-mediated conformational shift of phospholambanAllostery and binding cooperativity of the catalytic subunit of protein kinase A by NMR spectroscopy and molecular dynamics simulations.Nuclear Magnetic Resonance Structure and Binding Studies of PqqD, a Chaperone Required in the Biosynthesis of the Bacterial Dehydrogenase Cofactor Pyrroloquinoline Quinone.Secondary structure, backbone dynamics, and structural topology of phospholamban and its phosphorylated and Arg9Cys-mutated forms in phospholipid bilayers utilizing 13C and 15N solid-state NMR spectroscopy.Functional and physical competition between phospholamban and its mutants provides insight into the molecular mechanism of gene therapy for heart failure.Probing the helical tilt and dynamic properties of membrane-bound phospholamban in magnetically aligned bicelles using electron paramagnetic resonance spectroscopy.Istaroxime stimulates SERCA2a and accelerates calcium cycling in heart failure by relieving phospholamban inhibition.cAMP-dependent protein kinase A selects the excited state of the membrane substrate phospholamban.Utilizing afterglow magnetization from cross-polarization magic-angle-spinning solid-state NMR spectroscopy to obtain simultaneous heteronuclear multidimensional spectraStructural and functional dynamics of an integral membrane protein complex modulated by lipid headgroup chargeCholesterol driven alteration of the conformation and dynamics of phospholamban in model membranes.Probing the interaction of Arg9Cys mutated phospholamban with phospholipid bilayers by solid-state NMR spectroscopy.1H-detected MAS solid-state NMR experiments enable the simultaneous mapping of rigid and dynamic domains of membrane proteins.Histone deacetylase activity modulates exercise-induced skeletal muscle plasticity in zebrafish (Danio rerio).Perturbations of Native Membrane Protein Structure in Alkyl Phosphocholine Detergents: A Critical Assessment of NMR and Biophysical Studies.
P2860
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P2860
Lipid-mediated folding/unfolding of phospholamban as a regulatory mechanism for the sarcoplasmic reticulum Ca2+-ATPase
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
Lipid-mediated folding/unfoldi ...... oplasmic reticulum Ca2+-ATPase
@en
Lipid-mediated folding/unfoldi ...... plasmic reticulum Ca2+-ATPase.
@nl
type
label
Lipid-mediated folding/unfoldi ...... oplasmic reticulum Ca2+-ATPase
@en
Lipid-mediated folding/unfoldi ...... plasmic reticulum Ca2+-ATPase.
@nl
prefLabel
Lipid-mediated folding/unfoldi ...... oplasmic reticulum Ca2+-ATPase
@en
Lipid-mediated folding/unfoldi ...... plasmic reticulum Ca2+-ATPase.
@nl
P2093
P2860
P50
P1476
Lipid-mediated folding/unfoldi ...... oplasmic reticulum Ca2+-ATPase
@en
P2093
Elizabeth L Lockamy
Gianluigi Veglia
Nathaniel J Traaseth
P2860
P304
P356
10.1016/J.JMB.2011.03.015
P407
P577
2011-03-17T00:00:00Z