about
First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes--Chapter 4: pre-clinical efficacy and complication data required to justThe multifactorial role of the 3Rs in shifting the harm-benefit analysis in animal models of diseaseSuccessful implementation of cooperative handling eliminates the need for restraint in a complex non-human primate disease model.Comparisons of phenotype and immunomodulatory capacity among rhesus bone-marrow-derived mesenchymal stem/stromal cells, multipotent adult progenitor cells, and dermal fibroblasts.The usefulness and limitations of the diabetic macaque model in evaluating long-term porcine islet xenograft survival.Validity of animal models of type 1 diabetes, and strategies to enhance their utility in translational research.The safety, efficacy and regulatory triangle in drug development: Impact for animal models and the use of animals.Xenotransplantation of islet cells: what can the non-human primate model bring for the evaluation of efficacy and safety?Cross-validation of commercial enzyme-linked immunosorbent assay and radioimmunoassay for porcine C-peptide concentration measurements in non-human primate serum.Extrahepatic islet transplantation with microporous polymer scaffolds in syngeneic mouse and allogeneic porcine modelsLong-term hepatic vascular access in the nonhuman primate for recurrent portal vein infusion.A comprehensive microbiological safety approach for agarose encapsulated porcine islets intended for clinical trials.Establishing a Large-Animal Model for In Vivo Reprogramming of Bile Duct Cells into Insulin-Secreting Cells to Treat Diabetes.Differences in glucose-stimulated insulin secretion in vitro of islets from human, nonhuman primate, and porcine origin.Effects of histone deacetylase inhibitor SAHA on effector and FOXP3+regulatory T cells in rhesus macaques.Risk factors associated with surgical site infection and the development of short-term complications in macaques undergoing indwelling vascular access port placement.Cyclosporine toxicity in immunosuppressed streptozotocin-diabetic nonhuman primates.Evaluation of commercial ELISA and RIA for measuring porcine C-peptide: implications for research.Pretreatment of donor pigs with a diet rich in soybean oil increases the yield of isolated islets.Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates.A completely biological "off-the-shelf" arteriovenous graft that recellularizes in baboons.Species incompatibilities in the pig-to-macaque islet xenotransplant model affect transplant outcome: a comparison with allotransplantation.Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta CellsManagement of adverse side-effects after chemotherapy in macaques as exemplified by streptozotocin: case studies and recommendationsSuccessful Isolation and Transplantation of Nonhuman Primate Islets Using a Novel Purified Enzyme BlendRefining the high-dose streptozotocin-induced diabetic non-human primate model: an evaluation of risk factors and outcomesA novel alternative placement site and technique for totally implantable vascular access ports in non-human primatesMeeting Report of the 33rd Annual Meeting of the Academy of Surgical Research: Summary of Presentations, Labs, and Workshops, Focusing on Experimental Surgery, Las Vegas, NV, October 4-6, 2017Commentary on: Is the renal subcapsular space the preferred site for clinical porcine islet xenotransplantation? Review article (Int J Surg 2019 Jul 30;69:100-107. https://doi.org/10.1016/j.ijsu.2019.07.032. [Epub ahead of print])Long-Term Management of Vascular Access Ports in Nonhuman Primates Used in Preclinical Efficacy and Tolerability StudiesPreliminary Evaluation of Sustained-release Compared with Conventional Formulations of Meloxicam in Sheep (Ovis aries)Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytesNoninvasive Fluorine-19 Magnetic Resonance Relaxometry Measurement of the Partial Pressure of Oxygen in Acellular Perfluorochemical-loaded Alginate Microcapsules Implanted in the Peritoneal Cavity of Nonhuman PrimatesMeeting Report of the 34th Annual Meeting of the Academy of Surgical Research: Summary of Presentations, Labs, and Workshops, Focusing on Experimental Surgery, Charleston, SC, September 26-28, 2018Meeting Report of the 35th Annual Meeting of the Academy of Surgical Research: Summary of Presentations, Labs, and Workshops, Focusing on Experimental Surgery, Clearwater Beach, FL, 25-27 September 2019
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description
hulumtuese
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researcher
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հետազոտող
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name
Melanie L Graham
@nl
Melanie L Graham
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Melanie L. Graham
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Melanie L. Graham
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type
label
Melanie L Graham
@nl
Melanie L Graham
@sl
Melanie L. Graham
@en
Melanie L. Graham
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prefLabel
Melanie L Graham
@nl
Melanie L Graham
@sl
Melanie L. Graham
@en
Melanie L. Graham
@es
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M-2536-2017
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P1153
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0000-0002-2475-6975