Targeted radiosensitization by the Chk1 inhibitor SAR-020106.
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Trial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapyTherapeutic Implications for Overcoming Radiation Resistance in Cancer TherapyImproving the efficacy of chemoradiation with targeted agentsChemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promisingStructure-based design, discovery and development of checkpoint kinase inhibitors as potential anticancer therapiesDownregulation of Mitochondrial Single Stranded DNA Binding Protein (SSBP1) Induces Mitochondrial Dysfunction and Increases the Radiosensitivity in Non-Small Cell Lung Cancer Cells.Telomere-binding protein TPP1 modulates telomere homeostasis and confers radioresistance to human colorectal cancer cells.Enhanced inhibition of clonogenic survival of human medulloblastoma cells by multimodal treatment with ionizing irradiation, epigenetic modifiers, and differentiation-inducing drugsTargeting chromatin to improve radiation response.From novel insights in molecular biology to targeted treatment approaches in head and neck cancer.Personalised Medicine: Genome Maintenance Lessons Learned from Studies in Yeast as a Model Organism.An orally bioavailable Chk1 inhibitor, CCT244747, sensitizes bladder and head and neck cancer cell lines to radiation.Mutations of the LIM protein AJUBA mediate sensitivity of head and neck squamous cell carcinoma to treatment with cell-cycle inhibitors.The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells.Targeted inhibition of ATR or CHEK1 reverses radioresistance in oral squamous cell carcinoma cells with distal chromosome arm 11q loss.Targeting head and neck cancer stem cells to overcome resistance to photon and carbon ion radiation.Downregulation of Ubiquitin-conjugating Enzyme UBE2D3 Promotes Telomere Maintenance and Radioresistance of Eca-109 Human Esophageal Carcinoma Cells.MK-8776, a novel Chk1 inhibitor, exhibits an improved radiosensitizing effect compared to UCN-01 by exacerbating radiation-induced aberrant mitosis.MK-8776, a novel chk1 kinase inhibitor, radiosensitizes p53-defective human tumor cells.Neoadjuvant olaparib targets hypoxia to improve radioresponse in a homologous recombination-proficient breast cancer model.ATR/CHK1 inhibitors and cancer therapy.Studies on DNA Damage Repair and Precision Radiotherapy for Breast Cancer.Combined ATR and DNA-PK Inhibition Radiosensitizes Tumor Cells Independently of Their p53 Status
P2860
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P2860
Targeted radiosensitization by the Chk1 inhibitor SAR-020106.
description
2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
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2012年學術文章
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2012年學術文章
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name
Targeted radiosensitization by the Chk1 inhibitor SAR-020106.
@en
Targeted radiosensitization by the Chk1 inhibitor SAR-020106.
@nl
type
label
Targeted radiosensitization by the Chk1 inhibitor SAR-020106.
@en
Targeted radiosensitization by the Chk1 inhibitor SAR-020106.
@nl
prefLabel
Targeted radiosensitization by the Chk1 inhibitor SAR-020106.
@en
Targeted radiosensitization by the Chk1 inhibitor SAR-020106.
@nl
P2093
P1476
Targeted radiosensitization by the Chk1 inhibitor SAR-020106
@en
P2093
Gerben R Borst
Ian Collins
James Good
Joan N Kyula
Kevin J Harrington
Marcel Verheij
Michelle D Garrett
Ned G Powell
Pascal Meier
Sari Neijenhuis
P304
P356
10.1016/J.IJROBP.2012.08.006
P407
P577
2012-09-14T00:00:00Z