An asymmetric synthesis of 1,2,4-trioxane anticancer agents via desymmetrization of peroxyquinols through a Brønsted acid catalysis cascade.
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Endoperoxide antimalarials: development, structural diversity and pharmacodynamic aspects with reference to 1,2,4-trioxane-based structural scaffoldPhosphazene-catalyzed desymmetrization of cyclohexadienones by dithiane addition.Thiourea-catalyzed enantioselective addition of indoles to pyrones: alkaloid cores with quaternary carbons.Discovery and enantiocontrol of axially chiral urazoles via organocatalytic tyrosine click reaction.Chiral Brønsted Acid Catalyzed Kinetic Resolutions.Enantioselective synthesis of hindered cyclic dialkyl ethers via catalytic oxa-Michael/Michael desymmetrization.Cytotoxicity of Endoperoxides from the Caribbean Sponge Plakortis halichondrioides towards Sensitive and Multidrug-Resistant Leukemia Cells: Acids vs. Esters Activity Evaluation.Synthesis of five- and six-membered cyclic organic peroxides: Key transformations into peroxide ring-retaining products.Recent progress on asymmetric organocatalytic construction of chiral cyclohexenone skeletons.Asymmetric transformations of achiral 2,5-cyclohexadienones.Asymmetric dearomatization of phenols.Organocatalytic enantioselective desymmetrisation.Catalytic asymmetric peroxidation of α,β-unsaturated nitroalkenes by a bifunctional organic catalyst.Stereoselective Synthesis of Dioxolanes and Oxazolidines via a Desymmetrization Acetalization/Michael Cascade.Cyclization-endoperoxidation cascade reactions of dienes mediated by a pyrylium photoredox catalyst.Racemic hemiacetals as oxygen-centered pronucleophiles triggering cascade 1,4-addition/Michael reaction through dynamic kinetic resolution under iminium catalysis. Development and mechanistic insights.Rhodium-catalyzed asymmetric arylative cyclization of meso-1,6-dienynes leading to enantioenriched cis-hydrobenzofurans.An expedient stereoselective and chemoselective synthesis of bicyclic oxazolidinones from quinols and isocyanates.A powerful hydrogen-bond-donating organocatalyst for the enantioselective intramolecular oxa-Michael reaction of α,β-unsaturated amides and esters.Organocatalytic asymmetric chlorinative dearomatization of naphthols.Novel series of 1,2,4-trioxane derivatives as antimalarial agents.Desymmetrization of Bisallylic Amides through Catalytic Enantioselective Bromocyclization with BINAP Monoxide.Chiral Phosphoric Acid-Catalyzed Enantioselective Formal [3+2] Cycloaddition of Azomethine Imines with Enecarbamates.Catalytic stereoselective cascade reactions of quinols with trifluoromethyl ketones: direct access to CF3-containing 1,3-dioxolanes.Asymmetric organocatalytic desymmetrization of 4,4-disubstituted cyclohexadienones at high pressure: a new powerful strategy for the synthesis of highly congested chiral cyclohexenones.Enantio- and diastereoselective assembly of tetrahydrofuran and tetrahydropyran skeletons with all-carbon-substituted quaternary stereocenters.Phosphoric acid catalyzed desymmetrization of bicyclic bislactones bearing an all-carbon stereogenic center: total syntheses of (-)-rhazinilam and (-)-leucomidine B.Enantioselective synthesis of cyclic quaternary α-amino acid derivatives by chiral phosphoric acid catalysis.Conjugate-base-stabilized Brønsted acids as asymmetric catalysts: enantioselective Povarov reactions with secondary aromatic amines.Reactions of mono- and bicyclic enol ethers with the I2–hydroperoxide systemSix Peroxide Groups in One Molecule - Synthesis of Nine-Membered Bicyclic Silyl Peroxides
P2860
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P2860
An asymmetric synthesis of 1,2,4-trioxane anticancer agents via desymmetrization of peroxyquinols through a Brønsted acid catalysis cascade.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
An asymmetric synthesis of 1,2 ...... ønsted acid catalysis cascade.
@en
An asymmetric synthesis of 1,2 ...... ønsted acid catalysis cascade.
@nl
type
label
An asymmetric synthesis of 1,2 ...... ønsted acid catalysis cascade.
@en
An asymmetric synthesis of 1,2 ...... ønsted acid catalysis cascade.
@nl
prefLabel
An asymmetric synthesis of 1,2 ...... ønsted acid catalysis cascade.
@en
An asymmetric synthesis of 1,2 ...... ønsted acid catalysis cascade.
@nl
P2093
P2860
P356
P1476
An asymmetric synthesis of 1,2 ...... ønsted acid catalysis cascade.
@en
P2093
Barbara J Rose
David M Rubush
Douglas H Thamm
Michelle A Morges
P2860
P304
13554-13557
P356
10.1021/JA3052427
P407
P577
2012-08-07T00:00:00Z