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Targeting radiation-resistant hypoxic tumour cells through ATR inhibition

Targeting radiation-resistant hypoxic tumour cells through ATR inhibition

http://www.wikidata.org/entity/Q39328356

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Trial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapy DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of Cancer Perspectives on the combination of radiotherapy and targeted therapy with DNA repair inhibitors in the treatment of pancreatic cancer CYP450 Enzymes Effect Oxygen-Dependent Reduction of Azide-Based Fluorogenic Dyes HIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion.Potentiation of tumor responses to DNA damaging therapy by the selective ATR inhibitor VX-970 ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses.Targeting lung cancer through inhibition of checkpoint kinases.Pharmacologic inhibition of ATR and ATM offers clinically important distinctions to enhancing platinum or radiation response in ovarian, endometrial, and cervical cancer cells.VE-821, an ATR inhibitor, causes radiosensitization in human tumor cells irradiated with high LET radiation Linking hypoxia, DNA damage and proliferation in multicellular tumor spheroids Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation.Common cancer-associated imbalances in the DNA damage response confer sensitivity to single agent ATR inhibition.The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo.Molecular targets and mechanisms of radiosensitization using DNA damage response pathways.ATR Kinase Inhibition Protects Non-cycling Cells from the Lethal Effects of DNA Damage and Transcription Stress.Inhibiting the DNA damage response as a therapeutic manoeuvre in cancer.Preclinical testing of an Atr inhibitor demonstrates improved response to standard therapies for esophageal cancer.ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A.Current concepts in clinical radiation oncology.Pharmacologic ATM but not ATR kinase inhibition abrogates p21-dependent G1 arrest and promotes gastrointestinal syndrome after total body irradiation.Radiosensitization by the ATR Inhibitor AZD6738 through Generation of Acentric Micronuclei.DNA damage sensing by the ATM and ATR kinases.Targeting chromatin to improve radiation response.Multifaceted control of DNA repair pathways by the hypoxic tumor microenvironment Molecular Pathways: Targeting ATR in Cancer Therapy Personalised Medicine: Genome Maintenance Lessons Learned from Studies in Yeast as a Model Organism.DNA replication stress and cancer: cause or cure?LC-MS/MS assay for the simultaneous quantitation of the ATM inhibitor AZ31 and the ATR inhibitor AZD6738 in mouse plasma.Targeting the ATR-CHK1 Axis in Cancer Therapy ATM activation in hypoxia - causes and consequences.The cell cycle checkpoint inhibitors in the treatment of leukemias.Radiosensitization of human leukemic HL-60 cells by ATR kinase inhibitor (VE-821): phosphoproteomic analysis.CH-01 is a hypoxia-activated prodrug that sensitizes cells to hypoxia/reoxygenation through inhibition of Chk1 and Aurora A.Development of pharmacodynamic biomarkers for ATR inhibitors.Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids Hypoxic stress facilitates acute activation and chronic downregulation of fanconi anemia proteins.ATR/CHK1 inhibitors and cancer therapy.Targeting Hypoxia to Improve Non-Small Cell Lung Cancer Outcome.Radiosensitisation in vivo by histone deacetylase inhibition with no increase in early normal tissue radiation toxicity.

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Targeting radiation-resistant hypoxic tumour cells through ATR inhibition

http://www.wikidata.org/entity/Q39328356

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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2012年學術文章

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name

Targeting radiation-resistant hypoxic tumour cells through ATR inhibition

@en

Targeting radiation-resistant hypoxic tumour cells through ATR inhibition.

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type

label

Targeting radiation-resistant hypoxic tumour cells through ATR inhibition

@en

Targeting radiation-resistant hypoxic tumour cells through ATR inhibition.

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prefLabel

Targeting radiation-resistant hypoxic tumour cells through ATR inhibition

@en

Targeting radiation-resistant hypoxic tumour cells through ATR inhibition.

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British Journal of Cancer

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Targeting radiation-resistant hypoxic tumour cells through ATR inhibition

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E M Hammond

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I M Pires

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J R Pollard

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M M Olcina

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P A Charlton

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W G McKenna

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P2860

Curing metastatic testicular cancer

The DNA-damage response in human biology and disease

Somatic mutations affect key pathways in lung adenocarcinoma

The combined status of ATM and p53 link tumor development with therapeutic response

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects

Cell-cycle checkpoints and cancer

ATR: an essential regulator of genome integrity

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

Molecular imaging of hypoxia.

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