The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells.
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Signaling in Effector Lymphocytes: Insights toward Safer ImmunotherapyMolecular mechanisms of T cell co-stimulation and co-inhibitionComparative Transcriptomic Analysis of Rectal Tissue from Beef Steers Revealed Reduced Host Immunity in Escherichia coli O157:H7 Super-SheddersA polymorphism in a phosphotyrosine signalling motif of CD229 (Ly9, SLAMF3) alters SH2 domain binding and T-cell activationFine specificity and molecular competition in SLAM family receptor signallingNK cell cytotoxicity mediated by 2B4 and NTB-A is dependent on SAP acting downstream of receptor phosphorylation.PDK1 orchestrates early NK cell development through induction of E4BP4 expression and maintenance of IL-15 responsivenessCRISPR-Mediated Slamf1Δ/Δ Slamf5Δ/Δ Slamf6Δ/Δ Triple Gene Disruption Reveals NKT Cell Defects but Not T Follicular Helper Cell DefectsCRISPR-Mediated Triple Knockout of SLAMF1, SLAMF5 and SLAMF6 Supports Positive Signaling Roles in NKT Cell Development.Overexpression of miR-155 causes expansion, arrest in terminal differentiation and functional activation of mouse natural killer cellsThe adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation.Properties of human blood monocytes. II. Monocytes from healthy adults are highly heterogeneous within and among individuals.Stepwise phosphorylation of p65 promotes NF-κB activation and NK cell responses during target cell recognition.SAP gene transfer restores cellular and humoral immune function in a murine model of X-linked lymphoproliferative disease.NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activationThe adaptor molecule signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) is essential in mechanisms involving the Fyn tyrosine kinase for induction and progression of collagen-induced arthritis.Deletion of Slam locus in mice reveals inhibitory role of SLAM family in NK cell responses regulated by cytokines and LFA-1.Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells.Controlling natural killer cell responses: integration of signals for activation and inhibition.EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase Cγ, Ca++, and Erk, leading to granule polarization.Familial hemophagocytic lymphohistiocytosis: when rare diseases shed light on immune system functioning.Molecular checkpoints controlling natural killer cell activation and their modulation for cancer immunotherapy.Modulation of SAP dependent T:B cell interactions as a strategy to improve vaccination.XLP: clinical features and molecular etiology due to mutations in SH2D1A encoding SAP.TGFβ promotes mesenchymal phenotype of pancreatic cancer cells, in part, through epigenetic activation of VAV1.Elotuzumab as a novel anti-myeloma immunotherapy.A hematopoietic cell-driven mechanism involving SLAMF6 receptor, SAP adaptors and SHP-1 phosphatase regulates NK cell education.DNAM-1 controls NK cell activation via an ITT-like motif.NK cell education via nonclassical MHC and non-MHC ligands.Novel anti-myeloma immunotherapies targeting the SLAM family of receptors.SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin.Programmed differentiated natural killer cells kill leukemia cells by engaging SLAM family receptors.Dissection of SAP-dependent and SAP-independent SLAM family signaling in NKT cell development and humoral immunity.XLP1 inhibitory effect by 2B4 does not affect DNAM-1 and NKG2D activating pathways in NK cells.Immune cell inhibition by SLAMF7 is mediated by a mechanism requiring src kinases, CD45, and SHIP-1 that is defective in multiple myeloma cells.Spores of two probiotic Bacillus species enhance cellular immunity in BALB/C mice.Mining the Complex Family of Protein Tyrosine Phosphatases for Checkpoint Regulators in Immunity.SAP and Lessons Learned from a Primary Immunodeficiency.X-Linked Lymphoproliferative Disease Type 1: A Clinical and Molecular Perspective.Signals Controlling Lytic Granule Polarization at the Cytotoxic Immune Synapse.
P2860
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P2860
The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
The adaptor SAP controls NK ce ...... conjugates with target cells.
@en
The adaptor SAP controls NK ce ...... conjugates with target cells.
@nl
type
label
The adaptor SAP controls NK ce ...... conjugates with target cells.
@en
The adaptor SAP controls NK ce ...... conjugates with target cells.
@nl
prefLabel
The adaptor SAP controls NK ce ...... conjugates with target cells.
@en
The adaptor SAP controls NK ce ...... conjugates with target cells.
@nl
P2093
P1433
P1476
The adaptor SAP controls NK ce ...... conjugates with target cells.
@en
P2093
André Veillette
Dominique Davidson
Luis Alberto Pérez-Quintero
Tomohiro Kurosaki
Wojciech Swat
Zhongjun Dong
P304
P356
10.1016/J.IMMUNI.2012.03.023
P407
P577
2012-06-07T00:00:00Z