Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction.
about
Two Effective Routes for Removing Lineage Restriction Roadblocks: From Somatic Cells to HepatocytesHistone deacetylase inhibitor valproic acid promotes the differentiation of human induced pluripotent stem cells into hepatocyte-like cellsAggregate culture of human embryonic stem cell-derived hepatocytes in suspension are an improved in vitro model for drug metabolism and toxicity testing.Survival of primary human hepatocytes and death of induced pluripotent stem cells in media lacking glucose and arginine.HHEX promotes hepatic-lineage specification through the negative regulation of eomesodermin.Development and characterization of human-induced pluripotent stem cell-derived cholangiocytes.Distinctive features of single nucleotide alterations in induced pluripotent stem cells with different types of DNA repair deficiency disorders.CPM Is a Useful Cell Surface Marker to Isolate Expandable Bi-Potential Liver Progenitor Cells Derived from Human iPS Cells.Generation of enterocyte-like cells from human induced pluripotent stem cells for drug absorption and metabolism studies in human small intestineEngraftment of human induced pluripotent stem cell-derived hepatocytes in immunocompetent mice via 3D co-aggregation and encapsulation.Molecular dissection of HBV evasion from restriction factor tetherin: A new perspective for antiviral cell therapyThe Use of Induced Pluripotent Stem Cells for the Study and Treatment of Liver Diseases.Engraftment potential of spheroid-forming hepatic endoderm derived from human embryonic stem cells.Enhanced derivation of mouse ESC-derived cortical interneurons by expression of Nkx2.1.A set of microRNAs mediate direct conversion of human umbilical cord lining-derived mesenchymal stem cells into hepatocytes.Direct transdifferentiation of spermatogonial stem cells to morphological, phenotypic and functional hepatocyte-like cells via the ERK1/2 and Smad2/3 signaling pathways and the inactivation of cyclin A, cyclin B and cyclin ELong-term self-renewal of human ES/iPS-derived hepatoblast-like cells on human laminin 111-coated dishes.The human constitutive androstane receptor promotes the differentiation and maturation of hepatic-like cells.Prediction of Differentiation Tendency Toward Hepatocytes from Gene Expression in Undifferentiated Human Pluripotent Stem Cells.Utility of B-13 progenitor-derived hepatocytes in hepatotoxicity and genotoxicity studiesGeneration of a bile salt export pump deficiency model using patient-specific induced pluripotent stem cell-derived hepatocyte-like cellsHuman induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection.Stem cells in liver regeneration and their potential clinical applications.A mouse with humanized liver as an animal model for predicting drug effects and for studying hepatic viral infection: where to next?The road to regenerative liver therapies: the triumphs, trials and tribulations.An evaluation of the latest in vitro tools for drug metabolism studies.Bioartificial livers in vitro and in vivo: tailoring biocomponents to the expanding variety of applications.Relationships between the expression of hepatocyte nuclear factors and factors essential for lipoprotein production in a human mesenchymal stem cell line, UE7T-13.The Promise of New Technologies to Reduce, Refine, or Replace Animal Use while Reducing Risks of Drug Induced Liver Injury in Pharmaceutical Development.Endothelial cell-derived matrix promotes the metabolic functional maturation of hepatocyte via integrin-Src signalling.Enhanced Metabolizing Activity of Human ES Cell-Derived Hepatocytes Using a 3D Culture System with Repeated Exposures to Xenobiotics.Efficient Engraftment of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells in uPA/SCID Mice by Overexpression of FNK, a Bcl-xL Mutant Gene.Regenerative Medicine and the Biliary Tree.Triple Staining Including FOXA2 Identifies Stem Cell Lineages Undergoing Hepatic and Biliary Differentiation in Cirrhotic Human Liver.An In Vitro Human Liver Model by iPSC-Derived Parenchymal and Non-parenchymal Cells.Overexpression of transcription factor Foxa2 and Hnf1α induced rat bone mesenchymal stem cells into hepatocytes.Spheroid culture for enhanced differentiation of human embryonic stem cells to hepatocyte-like cellsThe basic helix-loop-helix transcription factor, Mist1, induces maturation of mouse fetal hepatoblasts.Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction.Oxygen drives hepatocyte differentiation and phenotype stability in liver cell lines.
P2860
Q26784188-B90F7951-9C83-4D5D-AC0D-F3DD8A3EB392Q28541550-DF6A9DDC-1B60-402C-9AE3-9BE394962A1CQ34048251-364C2F0F-509F-4723-8F33-99D0CB52ACEDQ34964650-3930FBCF-4A92-4AF5-9BE3-2DF34F5BB255Q35126482-E8E8DF41-AF80-461E-8FE5-04B7A49DE752Q35661071-E8936FF3-A877-4AEC-95B2-A1CCD4E8D191Q36023026-D4CC9F20-EFC5-4E46-982C-18254A5311B4Q36221162-E004DF9B-CCC9-4E5F-9CD3-806CFC62CA02Q36272752-7847CF05-AD9E-4204-97F6-18C16725DAAFQ36305534-3475A156-D40E-4CE5-A654-15A6F1331A1CQ36355811-BCF0483B-71A7-4A5D-BA8B-26BB494E8612Q36695546-73560F86-52C7-4360-871A-D0FA83903CC9Q36889821-FF967363-5721-4BBA-9FB3-E85415B71C57Q36971395-9DC00A9F-23A2-40E1-B166-BF781C2D4C37Q37357046-C9CC53E8-9D23-41E8-9DAB-87E7CE6063D4Q37360201-B7689BA3-36D5-4147-A346-23CA97B4AEE4Q37360935-2BC299FE-5162-4966-902F-3B7BAFF83823Q37414393-50311316-6C39-4F9F-A7D9-A6050585202FQ37513377-112BD415-019D-4966-AE29-59148CB47F24Q37537497-5BC2F089-0605-490A-B947-C1D6E85B673AQ37620655-784B93EE-8990-499E-9827-BF413AF506C7Q37736696-FA4D43B3-A8B2-4E07-BA18-FCBD85EAD6D8Q38092746-2E03D300-2AB8-4DB5-B510-10CEDAA4A618Q38131587-D4D7D42B-2B09-417F-85B7-20304DEB2DE0Q38140492-83202A5D-8EE7-4FDB-8487-2AE8CB5E8F13Q38160881-710897E9-9830-409E-92E3-D1B9AD03DBBEQ38264625-DD0328B1-BCE0-4E85-A66B-EA3B22C6F081Q38731497-BF90049E-E703-439E-A390-973309972608Q38774776-7D8C69A5-82F2-4FE6-BAEB-39B133BC52C2Q38805359-C2EEB47B-5871-4450-A478-7EE469EEB856Q38862327-EF09E2BE-9234-496C-BE95-C967CDD3AE93Q38997397-A0EFF56F-E283-43FC-8194-24B39628F245Q39136966-B374B136-8544-46AA-93C1-C10460671345Q39159595-FE40B7CC-AC9B-4B61-815F-2F348E0B3A6CQ41326722-E4D97AA0-448F-420F-A83A-3D9B09E05548Q41639621-6744E700-C6FC-41C6-B39A-7DFE10A643DEQ41863865-4BA02311-3073-46FF-A5C3-6E100891B244Q42151549-49304EDB-7185-4EB6-9038-26032EF84F45Q47218544-3492AA0E-31BC-4642-8E31-FA9D1566FF27Q48108728-7546F9A5-C90E-4C7A-97F3-B48DFC699C38
P2860
Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Generation of metabolically fu ...... FOXA2 and HNF1α transduction.
@en
Generation of metabolically fu ...... FOXA2 and HNF1α transduction.
@nl
type
label
Generation of metabolically fu ...... FOXA2 and HNF1α transduction.
@en
Generation of metabolically fu ...... FOXA2 and HNF1α transduction.
@nl
prefLabel
Generation of metabolically fu ...... FOXA2 and HNF1α transduction.
@en
Generation of metabolically fu ...... FOXA2 and HNF1α transduction.
@nl
P2093
P1476
Generation of metabolically fu ...... FOXA2 and HNF1α transduction.
@en
P2093
Fuminori Sakurai
Hitoshi Watanabe
Katsuhisa Tashiro
Kazuo Takayama
Kenji Kawabata
Kiyomi Kikuchi
Maiko Higuchi
Michiko Sugawara
Miho Kusuda Furue
Mitsuru Inamura
P304
P356
10.1016/J.JHEP.2012.04.038
P577
2012-05-29T00:00:00Z