A key regulator of cholesterol homoeostasis, SREBP-2, can be targeted in prostate cancer cells with natural products.
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The Impact of Vitamin E and Other Fat-Soluble Vitamins on Alzheimer´s DiseaseGeranylgeraniol suppresses the viability of human DU145 prostate carcinoma cells and the level of HMG CoA reductaseATAD3 gene cluster deletions cause cerebellar dysfunction associated with altered mitochondrial DNA and cholesterol metabolism.Fatostatin displays high antitumor activity in prostate cancer by blocking SREBP-regulated metabolic pathways and androgen receptor signaling.Does changing androgen receptor status during prostate cancer development impact upon cholesterol homeostasis?Neuregulin-activated ERBB4 induces the SREBP-2 cholesterol biosynthetic pathway and increases low-density lipoprotein uptakeAnti-cancer efficacy of SREBP inhibitor, alone or in combination with docetaxel, in prostate cancer harboring p53 mutations.Sugar Makes Fat by Talking to SCAPThe role of cholesterol metabolism and cholesterol transport in carcinogenesis: a review of scientific findings, relevant to future cancer therapeutics.Synergistic Impact of d-δ-Tocotrienol and Geranylgeraniol on the Growth and HMG CoA Reductase of Human DU145 Prostate Carcinoma Cells.Tocotrienol Affects Oxidative Stress, Cholesterol Homeostasis and the Amyloidogenic Pathway in Neuroblastoma Cells: Consequences for Alzheimer's DiseaseOncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP.The interplay between cell signalling and the mevalonate pathway in cancer.Overexpression of a key regulator of lipid homeostasis, Scap, promotes respiration in prostate cancer cells.Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner.A novel role for CRTC2 in hepatic cholesterol synthesis through SREBP-2.Cholesterol impairment contributes to neuroserpin aggregation.Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth.Betulin inhibits lung carcinoma proliferation through activation of AMPK signaling.Simvastatin Therapy for Drug Repositioning to Reduce the Risk of Prostate Cancer Mortality in Patients With Hyperlipidemia.Cholesterol synthesis pathway genes in prostate cancer are transcriptionally downregulated when tissue confounding is minimized.
P2860
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P2860
A key regulator of cholesterol homoeostasis, SREBP-2, can be targeted in prostate cancer cells with natural products.
description
2012 nî lūn-bûn
@nan
2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
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2012年學術文章
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2012年學術文章
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name
A key regulator of cholesterol ...... r cells with natural products.
@en
A key regulator of cholesterol ...... r cells with natural products.
@nl
type
label
A key regulator of cholesterol ...... r cells with natural products.
@en
A key regulator of cholesterol ...... r cells with natural products.
@nl
prefLabel
A key regulator of cholesterol ...... r cells with natural products.
@en
A key regulator of cholesterol ...... r cells with natural products.
@nl
P2860
P356
P1433
P1476
A key regulator of cholesterol ...... er cells with natural products
@en
P2093
Andrew J Brown
P2860
P304
P356
10.1042/BJ20120545
P407
P577
2012-09-01T00:00:00Z