Integrin α5β1 plays a critical role in resistance to temozolomide by interfering with the p53 pathway in high-grade glioma.
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β1 integrin targeting potentiates antiangiogenic therapy and inhibits the growth of bevacizumab-resistant glioblastomaβ1 Integrins as Therapeutic Targets to Disrupt Hallmarks of CancerMechanisms of neovascularization and resistance to anti-angiogenic therapies in glioblastoma multiformeThree-Dimensional Microfluidic Tri-Culture Model of the Bone Marrow Microenvironment for Study of Acute Lymphoblastic LeukemiaIntegrins in the Spotlight of Cancerp53 in cell invasion, podosomes, and invadopodiaA Bioengineered Peptide that Localizes to and Illuminates Medulloblastoma: A New Tool with Potential for Fluorescence-Guided Surgical ResectionEffects of connective tissue growth factor (CTGF) gene silencing on the radiosensitivity of glioblastomaA multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinomaIdentification of novel genetic alterations in samples of malignant glioma patients.CD151-α3β1 integrin complexes are prognostic markers of glioblastoma and cooperate with EGFR to drive tumor cell motility and invasion.Tumor Suppressor WWOX and p53 Alterations and Drug Resistance in Glioblastomas.Bacitracin Inhibits the Migration of U87-MG Glioma Cells via Interferences of the Integrin Outside-in Signaling Pathway.Supervillin-mediated suppression of p53 protein enhances cell survival.Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortality.Engineered knottin peptide enables noninvasive optical imaging of intracranial medulloblastoma.Integrin α5β1 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade gliomaErythroid cells generated in the absence of specific β1-integrin heterodimers accumulate reactive oxygen species at homeostasis and are unable to mount effective antioxidant defenses.Targeting hyperactivated DNA-PKcs by KU0060648 inhibits glioma progression and enhances temozolomide therapy via suppression of AKT signaling.Loss of phosphodiesterase 4D mediates acquired triapine resistance via Epac-Rap1-Integrin signaling.Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors.Three-dimensional cancer models mimic cell-matrix interactions in the tumour microenvironment.Caveolin-1-negative head and neck squamous cell carcinoma primary tumors display increased epithelial to mesenchymal transition and prometastatic properties.p53 regulates cytoskeleton remodeling to suppress tumor progression.Modified Panax ginseng Extract Inhibits uPAR-Mediated α[Formula: see text]β1-Integrin Signaling by Modulating Caveolin-1 to Induce Early Apoptosis in Lung Cancer Cells.In vivo biokinetic and metabolic characterization of the ⁶⁸Ga-labelled α5β1-selective peptidomimetic FR366.Three-dimensional matrix stiffness and adhesive ligands affect cancer cell response to toxins.Membrane proteome analysis of glioblastoma cell invasion.Functions of the Tumor Suppressors p53 and Rb in Actin Cytoskeleton RemodelingTumor cohesion and glioblastoma cell dispersal.Expression/activation of α5β1 integrin is linked to the β-catenin signaling pathway to drive migration in glioma cells.Phase I trial of p28 (NSC745104), a non-HDM2-mediated peptide inhibitor of p53 ubiquitination in pediatric patients with recurrent or progressive central nervous system tumors: A Pediatric Brain Tumor Consortium Study.Integrins and p53 pathways in glioblastoma resistance to temozolomide.MicroRNA-141-3p promotes glioma cell growth and temozolomide resistance by directly targeting p53.Temozolomide suppresses MYC via activation of TAp63 to inhibit progression of human glioblastoma.Interest of integrins targeting in glioblastoma according to tumor heterogeneity and cancer stem cell paradigm: an update.Identification of LRP-1 as an endocytosis and recycling receptor for β1-integrin in thyroid cancer cells.Integrin α5 triggers the metastatic potential in renal cell carcinoma.Expression and Prognostic Significance of p53 in Glioma Patients: A Meta-analysis.RND1 regulates migration of human glioblastoma stem-like cells according to their anatomical localization and defines a prognostic signature in glioblastoma
P2860
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P2860
Integrin α5β1 plays a critical role in resistance to temozolomide by interfering with the p53 pathway in high-grade glioma.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Integrin α5β1 plays a critical ...... pathway in high-grade glioma.
@en
Integrin α5β1 plays a critical ...... pathway in high-grade glioma.
@nl
type
label
Integrin α5β1 plays a critical ...... pathway in high-grade glioma.
@en
Integrin α5β1 plays a critical ...... pathway in high-grade glioma.
@nl
prefLabel
Integrin α5β1 plays a critical ...... pathway in high-grade glioma.
@en
Integrin α5β1 plays a critical ...... pathway in high-grade glioma.
@nl
P2093
P50
P1433
P1476
Integrin α5β1 plays a critical ...... 3 pathway in high-grade glioma
@en
P2093
Anne Maglott
Catherine Bossert
Fanny Noulet
François Plenat
Hana Janouskova
Jacqueline Lehmann-Che
Jan Teisinger
Julien Godet
Monique Dontenwill
Natacha Entz-Werle
P304
P356
10.1158/0008-5472.CAN-11-4199
P407
P577
2012-05-16T00:00:00Z