The HDAC inhibitor Givinostat modulates the hematopoietic transcription factors NFE2 and C-MYB in JAK2(V617F) myeloproliferative neoplasm cells.
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Evolving Therapeutic Strategies for the Classic Philadelphia-Negative Myeloproliferative NeoplasmsRegulation and function of the NFE2 transcription factor in hematopoietic and non-hematopoietic cellsMicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemiaInvestigational histone deacetylase inhibitors (HDACi) in myeloproliferative neoplasms.MYB deregulation from a EWSR1-MYB fusion at leukemic evolution of a JAK2 (V617F) positive primary myelofibrosis.MPL W515L expression induces TGFβ secretion and leads to an increase in chemokinesis via phosphorylation of THOC5.A phase II study of Givinostat in combination with hydroxycarbamide in patients with polycythaemia vera unresponsive to hydroxycarbamide monotherapy.The histone deacetylase inhibitor givinostat (ITF2357) exhibits potent anti-tumor activity against CRLF2-rearranged BCP-ALL.Genetic disruption of the KLF1 gene to overexpress the γ-globin gene using the CRISPR/Cas9 system.
P2860
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P2860
The HDAC inhibitor Givinostat modulates the hematopoietic transcription factors NFE2 and C-MYB in JAK2(V617F) myeloproliferative neoplasm cells.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
The HDAC inhibitor Givinostat ...... factors NFE2 and C-MYB in JAK2
@nl
The HDAC inhibitor Givinostat ...... oproliferative neoplasm cells.
@en
type
label
The HDAC inhibitor Givinostat ...... factors NFE2 and C-MYB in JAK2
@nl
The HDAC inhibitor Givinostat ...... oproliferative neoplasm cells.
@en
prefLabel
The HDAC inhibitor Givinostat ...... factors NFE2 and C-MYB in JAK2
@nl
The HDAC inhibitor Givinostat ...... oproliferative neoplasm cells.
@en
P2093
P50
P1476
The HDAC inhibitor Givinostat ...... oproliferative neoplasm cells.
@en
P2093
AGIMM Investigators
Alessandro Rambaldi
Anna Pellicioli
Ariel Amaru Calzada
Giacomo Tuana
Guido Finazzi
Luca Donadoni
Luigia Lombardi
Raffaella Gatta
Roberto Mantovani
P304
634-45.e10
P356
10.1016/J.EXPHEM.2012.04.007
P577
2012-05-08T00:00:00Z