Human embryonic stem cells fail to activate CHK1 and commit to apoptosis in response to DNA replication stress. - Wikidata - wikimedia - TriplyDB

Human embryonic stem cells fail to activate CHK1 and commit to apoptosis in response to DNA replication stress.

Human embryonic stem cells fail to activate CHK1 and commit to apoptosis in response to DNA replication stress.

http://www.wikidata.org/entity/Q39354618

about

Developmental insights from early mammalian embryos and core signaling pathways that influence human pluripotent cell growth and differentiation.Human pluripotent stem cells have a novel mismatch repair-dependent damage response.CDK1 plays an important role in the maintenance of pluripotency and genomic stability in human pluripotent stem cells Stem cells: the pursuit of genomic stability.Concise review: workshop review: understanding and assessing the risks of stem cell-based therapies Whole genome RNAi screens reveal a critical role of REV3 in coping with replication stress.Extensive RPA2 hyperphosphorylation promotes apoptosis in response to DNA replication stress in CHK1 inhibited cells Human Pluripotent Stem Cells and Derived Neuroprogenitors Display Differential Degrees of Susceptibility to BH3 Mimetics ABT-263, WEHI-539 and ABT-199 Genetic stability of pluripotent stem cells during anti-cancer therapies Conditional mutation of Smc5 in mouse embryonic stem cells perturbs condensin localization and mitotic progression The novel Chk1 inhibitor MK-8776 sensitizes human leukemia cells to HDAC inhibitors by targeting the intra-S checkpoint and DNA replication and repair.Lessons learned about human stem cell responses to ionizing radiation exposures: a long road still ahead of us.A mechanism for 1,4-Benzoquinone-induced genotoxicity.Regulation of DNA Replication in Early Embryonic Cleavages.Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies.Quality control: Genome maintenance in pluripotent stem cells.Technical approaches to induce selective cell death of pluripotent stem cells.Apoptosis and failure of checkpoint kinase 1 activation in human induced pluripotent stem cells under replication stress.Induced Pluripotent Stem Cells: Advances in the Quest for Genetic Stability during Reprogramming Process.Inhibitors of cell cycle checkpoints and DNA replication cause different responses in normal versus malignant urothelial cells.Human embryonic and induced pluripotent stem cells express TRAIL receptors and can be sensitized to TRAIL-induced apoptosis.Acquired Genetic and Epigenetic Variation in Human Pluripotent Stem Cells.Unraveling the Inconsistencies of Cardiac Differentiation Efficiency Induced by the GSK3β Inhibitor CHIR99021 in Human Pluripotent Stem Cells.

P2860

Q33822777-07C006E8-3720-48F4-B5C0-0113A2CD8BFE Q34107260-281A3D6C-376A-4B2F-B88F-B312622117D0 Q34662178-9144322A-B63E-4FEF-9069-68B4E2D0134F Q34685564-529D832F-4812-47D1-AAAF-BA5C813BF43D Q35200156-4D47A304-882C-4D25-8B2E-4A4FDE4AE648 Q35223093-3D987AC9-F69B-4AA6-8184-11F1113488F7 Q35745476-45837C03-7A99-4083-9D27-0E51B63EAC1B Q35974864-81758C6C-FDB2-4FA2-8072-19EC86AB56D9 Q36639903-2745E4D6-A895-4946-AEEC-0189B4673932 Q36856933-97E83378-D3E0-4497-BDCE-CF9C134D87CB Q36927012-72BB470D-D9C5-4DF1-9B71-A23C185C132F Q37139081-5651349D-D287-440D-AF94-B823158FC7A0 Q37564763-CAD1C7CE-18AF-4C3A-8BF7-00B6F4BC136F Q37628282-05EB52ED-6CD3-428A-BA78-683323235BAF Q37666328-88C9148E-213A-4D88-93F5-48EDFCC36F15 Q38180443-028CC8E5-C522-40CB-818F-7E755D598F0F Q39155502-9C6E4DB9-FC44-404E-B2D4-45F64FEA205B Q40062343-1B4F1306-258F-4471-95D0-149CA8D2B48D Q41660631-5C92B5DE-2CFE-411D-9A63-30E3A0D2BEFF Q41874558-EF40AA9A-E01C-4F24-BA8E-92FB478CCA87 Q42915261-64B7DC10-86EC-4399-8F16-058FED590796 Q50085968-57939C0F-2ECF-4CB2-870F-55AA185EC6A5 Q52715883-37AFDE20-EEC3-479E-84FD-570A91AB24E7

P2860

Human embryonic stem cells fail to activate CHK1 and commit to apoptosis in response to DNA replication stress.

http://www.wikidata.org/entity/Q39354618

description

2012 nî lūn-bûn

@nan

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

2012年论文

@zh

2012年论文

@zh-cn

name

Human embryonic stem cells fai ...... nse to DNA replication stress.

@en

Human embryonic stem cells fai ...... nse to DNA replication stress.

@nl

type

label

Human embryonic stem cells fai ...... nse to DNA replication stress.

@en

Human embryonic stem cells fai ...... nse to DNA replication stress.

@nl

prefLabel

Human embryonic stem cells fai ...... nse to DNA replication stress.

@en

Human embryonic stem cells fai ...... nse to DNA replication stress.

@nl

P1433

Q39354618-F02006F5-D766-4CAE-BE22-8075F75A2D32

P1476

Q39354618-20D93E53-30C5-4529-81E6-399B92AC244B

P2093

Q39354618-335BB2EE-5350-4F8E-8923-DE47D9F8A52F

Q39354618-7C1BA6C9-BE15-4038-BAEE-09CE68F67347

Q39354618-84DC6A58-4CF0-4906-B3BA-8B8623108CA5

Q39354618-BC773AD8-A06C-46CD-BFB4-B9CD77FFFDDD

Q39354618-C9884609-14BC-42B0-AAFC-D7A2A3560D77

Q39354618-F2C4A764-FB93-41E0-8EC7-142594F7BB15

P2860

Q39354618-09B9B69F-F3EC-45FA-A953-11A4C34E5B5F

Q39354618-10016F38-A356-4E95-8906-7534C3C88663

Q39354618-12F488BB-D711-4FC8-9AA6-C9E9D7780282

Q39354618-2B4D6BBA-89FA-4BB8-96FB-65075DAD555A

Q39354618-3E93C7A3-8401-47E1-97AE-EFA9F18CD57C

Q39354618-3F8D7AAD-8FE9-439D-AF28-FFB0C4AB2999

Q39354618-478A3CD5-EAE8-4DC2-A181-03138B64CC53

Q39354618-493F8B1C-B826-4058-838F-53AD891F9FA9

Q39354618-4DF65FE1-35B4-48F1-9B05-7D901A563F89

Q39354618-50150F36-1B47-40C4-BB58-7CF3BBB51EC4

P304

Q39354618-CD65EDF9-DDCB-486D-A69F-ABDE516E5FA6

P31

Q39354618-5297F616-0028-4FCC-8E63-A90BB52A728C

P356

Q39354618-CF03D778-1AA2-4514-B8B3-E7C0B7455D4A

P433

Q39354618-071C0669-5701-47D4-85F1-0A53734F6A9E

P478

Q39354618-612A10C9-D4DD-41BF-AEAB-5B44E0A57BF1

P577

Q39354618-8AC0A90E-2932-4495-9ABE-BF8AFB91C231

P5875

Q39354618-C78D1425-CF16-4593-81B9-41CE1BE336E3

P698

Q39354618-3C6C1560-E251-4019-95A2-2B1AA7FB7468

P356

P1433

P1476

Human embryonic stem cells fai ...... nse to DNA replication stress.

@en

P2093

Gregg Bingham

http://www.w3.org/2001/XMLSchema#string

Joëlle A Desmarais

http://www.w3.org/2001/XMLSchema#string

Mark Meuth

http://www.w3.org/2001/XMLSchema#string

Mary E Gagou

http://www.w3.org/2001/XMLSchema#string

Michele J Hoffmann

http://www.w3.org/2001/XMLSchema#string

Peter W Andrews

http://www.w3.org/2001/XMLSchema#string

P2860

Chk1 suppressed cell death

The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis

Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.

Chk1 and p21 cooperate to prevent apoptosis during DNA replication fork stress

Embryonic stem cell lines derived from human blastocysts

The DNA Damage Response: Making It Safe to Play with Knives

Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139

ATR: an essential regulator of genome integrity

Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage

P304

1385-1393

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1002/STEM.1117

http://www.w3.org/2001/XMLSchema#string

P433

7

http://www.w3.org/2001/XMLSchema#string

P478

30

http://www.w3.org/2001/XMLSchema#string

P577

2012-07-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

224888882

http://www.w3.org/2001/XMLSchema#string

P698

22553144

http://www.w3.org/2001/XMLSchema#string