Synthetic essentiality: Targeting tumor suppressor deficiencies in cancer.

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Cutting down the time to identify challenging tumor therapeutic targets and drug combinations using synthetic lethal approaches.Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer.

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Synthetic essentiality: Targeting tumor suppressor deficiencies in cancer.

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2017 nî lūn-bûn

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2017年の論文

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Synthetic essentiality: Targeting tumor suppressor deficiencies in cancer.

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Synthetic essentiality: Targeting tumor suppressor deficiencies in cancer.

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Synthetic essentiality: Targeting tumor suppressor deficiencies in cancer.

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Synthetic essentiality: Targeting tumor suppressor deficiencies in cancer.

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Synthetic essentiality: Targeting tumor suppressor deficiencies in cancer.

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Synthetic essentiality: Targeting tumor suppressor deficiencies in cancer.

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P1476

Synthetic essentiality: Targeting tumor suppressor deficiencies in cancer.

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Di Zhao

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Ronald A DePinho

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P2860

Cancer vulnerabilities unveiled by genomic loss

A large-scale RNAi screen in human cells identifies new components of the p53 pathway

Passenger deletions generate therapeutic vulnerabilities in cancer

Multiplex genome engineering using CRISPR/Cas systems

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Mutations of the BRAF gene in human cancer

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

Global mapping of the yeast genetic interaction network.

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scholarly article

P356

10.1002/BIES.201700076

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English

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2017-07-04T00:00:00Z

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28675450

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Synthetic essentiality: Targeting tumor suppressor deficiencies in cancer.

about

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P2860

Synthetic essentiality: Targeting tumor suppressor deficiencies in cancer.

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