Central role of lactic acidosis in cancer cell resistance to glucose deprivation-induced cell death.
about
Anticancer strategies based on the metabolic profile of tumor cells: therapeutic targeting of the Warburg effectAutophagy: a targetable linchpin of cancer cell metabolismSchisandrin B attenuates cancer invasion and metastasis via inhibiting epithelial-mesenchymal transitionA nonrandomized cohort and a randomized study of local control of large hepatocarcinoma by targeting intratumoral lactic acidosisGlucose deprivation induces G2/M transition-arrest and cell death in N-GlcNAc2-modified protein-producing renal carcinoma cells.Beyond Warburg effect--dual metabolic nature of cancer cells.No evident dose-response relationship between cellular ROS level and its cytotoxicity--a paradoxical issue in ROS-based cancer therapy.Mechanisms by which low glucose enhances the cytotoxicity of metformin to cancer cells both in vitro and in vivo.Tumor environmental factors glucose deprivation and lactic acidosis induce mitotic chromosomal instability--an implication in aneuploid human tumors.Glucose promotes cell proliferation, glucose uptake and invasion in endometrial cancer cells via AMPK/mTOR/S6 and MAPK signalingLactic acidosis switches cancer cells from aerobic glycolysis back to dominant oxidative phosphorylation.Integrated omics-analysis reveals Wnt-mediated NAD+ metabolic reprogramming in cancer stem-like cells.The changing 50% inhibitory concentration (IC50) of cisplatin: a pilot study on the artifacts of the MTT assay and the precise measurement of density-dependent chemoresistance in ovarian cancer.Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine: implications for cancer therapies.Metabolomic characterisation of the effects of oncogenic PIK3CA transformation in a breast epithelial cell line.Quantification of lactate from various metabolic pathways and quantification issues of lactate isotopologues and isotopmers.Evidence of drug-response heterogeneity rapidly generated from a single cancer cell.Nutrient deprivation-related OXPHOS/glycolysis interconversion via HIF-1α/C-MYC pathway in U251 cells.Elucidation of drivers of high-level production of lactates throughout a cancer development.Dual inhibition of glycolysis and glutaminolysis as a therapeutic strategy in the treatment of ovarian cancerCalcium homeostasis and ER stress in control of autophagy in cancer cellsTumor Microenvironment-Enabled Nanotherapy.Targeting therapy-resistant cancer stem cells by hyperthermia.
P2860
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P2860
Central role of lactic acidosis in cancer cell resistance to glucose deprivation-induced cell death.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Central role of lactic acidosi ...... eprivation-induced cell death.
@en
Central role of lactic acidosi ...... eprivation-induced cell death.
@nl
type
label
Central role of lactic acidosi ...... eprivation-induced cell death.
@en
Central role of lactic acidosi ...... eprivation-induced cell death.
@nl
prefLabel
Central role of lactic acidosi ...... eprivation-induced cell death.
@en
Central role of lactic acidosi ...... eprivation-induced cell death.
@nl
P2093
P2860
P356
P1476
Central role of lactic acidosi ...... eprivation-induced cell death.
@en
P2093
Chunyan Dai
Danqing Hu
Feifei Sun
Jiansheng Xie
Zonghui Ding
P2860
P304
P356
10.1002/PATH.3978
P577
2012-02-17T00:00:00Z