about
The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicityNanoscale spatially resolved infrared spectra from single microdroplets.Detecting nanoscale vibrations as signature of lifeInfrared nanospectroscopy characterization of oligomeric and fibrillar aggregates during amyloid formation.Nanoscale studies link amyloid maturity with polyglutamine diseases onset.AFM-Based Single Molecule Techniques: Unraveling the Amyloid Pathogenic Species.A critical concentration of N-terminal pyroglutamylated amyloid beta drives the misfolding of Ab1-42 into more toxic aggregates.Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species.Silk micrococoons for protein stabilisation and molecular encapsulationAmyloid single-cell cytotoxicity assays by nanomotion detection.Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6.Influence of the β-sheet content on the mechanical properties of aggregates during amyloid fibrillization.FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions.Concentration-dependent and surface-assisted self-assembly properties of a bioactive estrogen receptor α-derived peptideMolecular determinants of the interaction of EGCG with ordered and disordered proteinsMicrofluidic deposition for resolving single-molecule protein architecture and heterogeneityStabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc IonsIdentification of Oxidative Stress in Red Blood Cells with Nanoscale Chemical Resolution by Infrared NanospectroscopySolution fibre spinning technique for the fabrication of tuneable decellularised matrix-laden fibres and fibrous micromembranesDetermination of Polypeptide Conformation with Nanoscale Resolution in WaterIdentification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrilsCholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranesWater-Dispersible Polydopamine-Coated Nanofibers for Stimulation of Neuronal Growth and AdhesionTrodusquemine enhances Aβ aggregation but suppresses its toxicity by displacing oligomers from cell membranesMeasurement of intrinsic properties of amyloid fibrils by the peak force QNM methodDifferent soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanismsAtomic force microscopy for single molecule characterisation of protein aggregationN-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting.Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its OligomersThe Influence of Pathogenic Mutations in α-Synuclein on Biophysical and Structural Characteristics of Amyloid FibrilsInfrared nanospectroscopic mapping of a single metaphase chromosomeCharacterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force MicroscopyNanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detectionFabrication and Characterization of Reconstituted Silk Microgels for the Storage and Release of Small MoleculesSoluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progressionAnalysis of αB-crystallin polydispersity in solution through native microfluidic electrophoresisRational design of a conformation-specific antibody for the quantification of Aβ oligomersSingle molecule secondary structure determination of proteins through infrared absorption nanospectroscopy
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Francesco Simone Ruggeri
@ast
Francesco Simone Ruggeri
@en
Francesco Simone Ruggeri
@es
Francesco Simone Ruggeri
@nl
Francesco Simone Ruggeri
@sl
type
label
Francesco Simone Ruggeri
@ast
Francesco Simone Ruggeri
@en
Francesco Simone Ruggeri
@es
Francesco Simone Ruggeri
@nl
Francesco Simone Ruggeri
@sl
prefLabel
Francesco Simone Ruggeri
@ast
Francesco Simone Ruggeri
@en
Francesco Simone Ruggeri
@es
Francesco Simone Ruggeri
@nl
Francesco Simone Ruggeri
@sl
P1053
C-8004-2012
P106
P1153
55314445700
P1960
PPuFbGcAAAAJ
P21
P31
P3829
P3835
francesco-simone-ruggeri
P496
0000-0002-1232-1907