Biochemical study of the comparative inhibition of hepatitis C virus RNA polymerase by VX-222 and filibuvir.
about
Inhibitors of the Hepatitis C Virus Polymerase; Mode of Action and ResistanceSimilar prevalence of low-abundance drug-resistant variants in treatment-naive patients with genotype 1a and 1b hepatitis C virus infections as determined by ultradeep pyrosequencingBiophysical Mode-of-Action and Selectivity Analysis of Allosteric Inhibitors of Hepatitis C Virus (HCV) Polymerase.Inhibitors of the tick-borne, hemorrhagic fever-associated flaviviruses.Understanding the drug resistance mechanism of hepatitis C virus NS5B to PF-00868554 due to mutations of the 423 site: a computational study.Cross-genotypic examination of hepatitis C virus polymerase inhibitors reveals a novel mechanism of action for thumb bindersSubgenomic promoter recognition by the norovirus RNA-dependent RNA polymerases.Identification of novel anti-hepatitis C virus agents by a quantitative high throughput screen in a cell-based infection assay.Preclinical characterization of GS-9669, a thumb site II inhibitor of the hepatitis C virus NS5B polymeraseDe Novo RNA Synthesis by RNA-Dependent RNA Polymerase Activity of Telomerase Reverse TranscriptaseThe molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection.Genotypic and phenotypic analyses of hepatitis C virus variants observed in clinical studies of VX-222, a nonnucleoside NS5B polymerase inhibitorHepatitis C Virus NS4B Can Suppress STING Accumulation To Evade Innate Immune ResponsesThe juxtamembrane sequence of the Hepatitis C virus polymerase can affect RNA synthesis and inhibition by allosteric polymerase inhibitors.The murine norovirus core subgenomic RNA promoter consists of a stable stem-loop that can direct accurate initiation of RNA synthesis.Restoration of the activated Rig-I pathway in hepatitis C virus (HCV) replicon cells by HCV protease, polymerase, and NS5A inhibitors in vitro at clinically relevant concentrations.NMR reveals the intrinsically disordered domain 2 of NS5A protein as an allosteric regulator of the hepatitis C virus RNA polymerase NS5B.Isolation and characterization of hepatitis C virus resistant to a novel phenanthridinone derivative.Purification and Biochemical Characterisation of Rabbit Calicivirus RNA-Dependent RNA Polymerases and Identification of Non-Nucleoside InhibitorsAntiviral response and resistance analysis of treatment-naïve HCV-infected patients receiving single and multiple doses of GS-9190.Interferon-free regimens containing setrobuvir for patients with genotype 1 chronic hepatitis C: a randomized, multicenter study.Computational study on the drug resistance mechanism of HCV NS3 protease to BMS-605339.Structural and regulatory elements of HCV NS5B polymerase--β-loop and C-terminal tail--are required for activity of allosteric thumb site II inhibitors.Global elimination of hepatitis C virus infection: Progresses and the remaining challenges.
P2860
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P2860
Biochemical study of the comparative inhibition of hepatitis C virus RNA polymerase by VX-222 and filibuvir.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
Biochemical study of the compa ...... erase by VX-222 and filibuvir.
@en
Biochemical study of the compa ...... erase by VX-222 and filibuvir.
@nl
type
label
Biochemical study of the compa ...... erase by VX-222 and filibuvir.
@en
Biochemical study of the compa ...... erase by VX-222 and filibuvir.
@nl
prefLabel
Biochemical study of the compa ...... erase by VX-222 and filibuvir.
@en
Biochemical study of the compa ...... erase by VX-222 and filibuvir.
@nl
P2093
P2860
P356
P1476
Biochemical study of the compa ...... erase by VX-222 and filibuvir.
@en
P2093
Baochang Fan
C Cheng Kao
C T Ranjith-Kumar
Charlotte Soulard
David B Smith
Guanghui Yi
Jerome Deval
Lawrence Blatt
Leonid Beigelman
P2860
P304
P356
10.1128/AAC.05438-11
P407
P577
2011-12-05T00:00:00Z