Disruption of p16 and activation of Kras in pancreas increase ductal adenocarcinoma formation and metastasis in vivo
about
Genetics and biology of pancreatic ductal adenocarcinomaRAS isoforms and mutations in cancer at a glanceUtilizing past and present mouse systems to engineer more relevant pancreatic cancer modelsKRAS mutant allele-specific imbalance is associated with worse prognosis in pancreatic cancer and progression to undifferentiated carcinoma of the pancreasEnhanced serum methylated p16 DNAs is associated with the progression of gastric cancerDevelopment of orthotopic pancreatic tumor mouse modelsOrigin of metastases: subspecies of cancers generated by intrinsic karyotypic variations.Drugging the undruggable RAS: Mission possible?Human adipose tissue-derived stem cells cultured in xeno-free culture condition enhance c-MYC expression increasing proliferation but bypassing spontaneous cell transformation.Clinical significance of the genetic landscape of pancreatic cancer and implications for identification of potential long-term survivors.Hypoxia-induced endoplasmic reticulum stress characterizes a necrotic phenotype of pancreatic cancer.Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberineMutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response.Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes.Common drugs and treatments for cancer and age-related diseases: revitalizing answers to NCI's provocative questions.Combining hedgehog signaling inhibition with focal irradiation on reduction of pancreatic cancer metastasis.Altered transcriptome signature of phenotypically normal skin fibroblasts heterozygous for CDKN2A in familial melanoma: relevance to early interventionPancreatic cancer-associated retinoblastoma 1 dysfunction enables TGF-β to promote proliferation.Challenges and advances in mouse modeling for human pancreatic tumorigenesis and metastasisCDK4/6-inhibiting drug substitutes for p21 and p16 in senescence: duration of cell cycle arrest and MTOR activity determine geroconversion.Analysis of the tumor-initiating and metastatic capacity of PDX1-positive cells from the adult pancreas.Relevance of animal models of pancreatic cancer and pancreatitis to human disease.The role of wild type RAS isoforms in cancer.A novel long non-coding RNA ENST00000480739 suppresses tumour cell invasion by regulating OS-9 and HIF-1α in pancreatic ductal adenocarcinoma.Loss of Activin Receptor Type 1B Accelerates Development of Intraductal Papillary Mucinous Neoplasms in Mice With Activated KRAS.Mutant allele specific imbalance in oncogenes with copy number alterations: Occurrence, mechanisms, and potential clinical implications.KRAS: The Critical Driver and Therapeutic Target for Pancreatic Cancer.Pancreatic DCLK1+ cells originate distinctly from PDX1+ progenitors and contribute to the initiation of intraductal papillary mucinous neoplasm in mice.Targeting Epigenetic Aberrations in Pancreatic Cancer, a New Path to Improve Patient Outcomes?
P2860
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P2860
Disruption of p16 and activation of Kras in pancreas increase ductal adenocarcinoma formation and metastasis in vivo
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
Disruption of p16 and activati ...... rmation and metastasis in vivo
@en
Disruption of p16 and activati ...... mation and metastasis in vivo.
@nl
type
label
Disruption of p16 and activati ...... rmation and metastasis in vivo
@en
Disruption of p16 and activati ...... mation and metastasis in vivo.
@nl
prefLabel
Disruption of p16 and activati ...... rmation and metastasis in vivo
@en
Disruption of p16 and activati ...... mation and metastasis in vivo.
@nl
P2093
P2860
P50
P356
P1433
P1476
Disruption of p16 and activati ...... rmation and metastasis in vivo
@en
P2093
Andrew M Lowy
Chia-Yu Kuo
Dan E Arking
Dario Garcia-Carracedo
Doris Chen
Fikret Sahin
Gloria H Su
Wanglong Qiu
Wendy M Wang
P2860
P304
P356
10.18632/ONCOTARGET.357
P407
P577
2011-11-01T00:00:00Z