Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy.
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Autophagy in ageing and ageing-associated diseasesEvaluation of traditional medicines for neurodegenerative diseases using Drosophila modelsn-butylidenephthalide protects against dopaminergic neuron degeneration and α-synuclein accumulation in Caenorhabditis elegans models of Parkinson's diseaseFull component analysis of Tianma-Gouteng-YinA Randomized Controlled Trial of Chinese Medicine on Nonmotor Symptoms in Parkinson's Disease.High Throughput Sequencing Identifies MicroRNAs Mediating α-Synuclein Toxicity by Targeting Neuroactive-Ligand Receptor Interaction Pathway in Early Stage of Drosophila Parkinson's Disease Model.α-Synuclein oligomers and clinical implications for Parkinson disease.P73 and age-related diseases: is there any link with Parkinson Disease?Induction of reactive oxygen species-stimulated distinctive autophagy by chelerythrine in non-small cell lung cancer cells.Autophagy modulation for Alzheimer's disease therapy.Aberrant autophagy and parkinsonism: does correction rescue from disease progression?Impaired mitochondrial homeostasis and neurodegeneration: towards new therapeutic targets?Chinese Medicine: A Hope for Neurodegenerative Diseases?Neuroprotective Natural Products for the Treatment of Parkinson's Disease by Targeting the Autophagy-Lysosome Pathway: A Systematic Review.Therapeutic potential of autophagy-enhancing agents in Parkinson's disease.Novel pharmacological modulators of autophagy: an updated patent review (2012-2015).Targeted suppression of chaperone-mediated autophagy by miR-320a promotes α-synuclein aggregation.Corynoxine, a natural autophagy enhancer, promotes the clearance of alpha-synuclein via Akt/mTOR pathway.Holothuria scabra extracts exhibit anti-Parkinson potential in C. elegans: A model for anti-Parkinson testing.Curcumin ameliorates the neurodegenerative pathology in A53T α-synuclein cell model of Parkinson's disease through the downregulation of mTOR/p70S6K signaling and the recovery of macroautophagy.Autophagy as an Emerging Common Pathomechanism in Inherited Peripheral Neuropathies.HMGB1 is involved in autophagy inhibition caused by SNCA/α-synuclein overexpression: a process modulated by the natural autophagy inducer corynoxine B.Bioassay-Guided Isolation of Neuroprotective Compounds from Uncaria rhynchophylla against Beta-Amyloid-Induced Neurotoxicity.Neuroprotective Effects of β-Asarone Against 6-Hydroxy Dopamine-Induced Parkinsonism via JNK/Bcl-2/Beclin-1 Pathway.Isorhynchophylline Attenuates MPP+-Induced Apoptosis Through Endoplasmic Reticulum Stress- and Mitochondria-Dependent Pathways in PC12 Cells: Involvement of Antioxidant Activity.Alpha-synuclein oligomers: a new hope.Mini-review on initiatives to interfere with the propagation and clearance of alpha-synuclein in Parkinson's disease.Phosphoproteome-based kinase activity profiling reveals the critical role of MAP2K2 and PLK1 in neuronal autophagy.Stereoselective in vitro metabolism of rhynchophylline and isorhynchophylline epimers of Uncaria rhynchophylla in rat liver microsomes.Antidepressant-Like Effect of Isorhynchophylline in Mice.Pharmacological effects of active compounds on neurodegenerative disease with gastrodia and uncaria decoction, a commonly used poststroke decoction.Role of Plant Derived Alkaloids and Their Mechanism in Neurodegenerative Disorders.Fangchinoline accumulates autophagosomes by inhibiting autophagic degradation and promoting TFEB nuclear translocation
P2860
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P2860
Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Isorhynchophylline, a natural ...... cells via inducing autophagy.
@en
Isorhynchophylline, a natural ...... cells via inducing autophagy.
@nl
type
label
Isorhynchophylline, a natural ...... cells via inducing autophagy.
@en
Isorhynchophylline, a natural ...... cells via inducing autophagy.
@nl
prefLabel
Isorhynchophylline, a natural ...... cells via inducing autophagy.
@en
Isorhynchophylline, a natural ...... cells via inducing autophagy.
@nl
P2093
P50
P356
P1433
P1476
Isorhynchophylline, a natural ...... l cells via inducing autophagy
@en
P2093
Jie-Qiong Tan
Liang-Feng Liu
Zhuo-Hua Zhang
P304
P356
10.4161/AUTO.8.1.18313
P577
2012-01-01T00:00:00Z