Early prediction of instability of Chinese hamster ovary cell lines expressing recombinant antibodies and antibody-fusion proteins.
about
Combination of FACS and homologous recombination for the generation of stable and high-expression engineered cell linesEfficient recombinant production in mammalian cells using a novel IR/MAR gene amplification methodFusion of the Dhfr/Mtx and IR/MAR gene amplification methods produces a rapid and efficient method for stable recombinant protein production.Using molecular markers to characterize productivity in Chinese hamster ovary cell lines.Transcriptome study and identification of potential marker genes related to the stable expression of recombinant proteins in CHO clones.Impact of Different Promoters on Episomal Vectors Harbouring Characteristic Motifs of Matrix Attachment Regions.Matrix attachment region combinations increase transgene expression in transfected Chinese hamster ovary cellsUbiquitous Chromatin Opening Elements (UCOEs) effect on transgene position and expression stability in CHO cells following methotrexate (MTX) amplification.A framework to quantify karyotype variation associated with CHO cell line instability at a single-cell level.Genetic analyses of Per.C6 cell clones producing a therapeutic monoclonal antibody regarding productivity and long-term stability.Improving expression of recombinant human IGF-1 using IGF-1R knockout CHO cell lines.Deletion of a telomeric region on chromosome 8 correlates with higher productivity and stability of CHO cell lines.miR-143 targets MAPK7 in CHO cells and induces a hyperproductive phenotype to enhance production of difficult-to-express proteins.Expression of the human cytomegalovirus pentamer complex for vaccine use in a CHO system.Non-viral adeno-associated virus-based platform for stable expression of antibody combination therapeutics.Fast identification of reliable hosts for targeted cell line development from a limited-genome screening using combined φC31 integrase and CRE-Lox technologies.Determination of Chinese hamster ovary cell line stability and recombinant antibody expression during long-term culture.Impact of using different promoters and matrix attachment regions on recombinant protein expression level and stability in stably transfected CHO cells.Insertion of core CpG island element into human CMV promoter for enhancing recombinant protein expression stability in CHO cells.Genetic analysis of heterogeneous sub-clones in recombinant Chinese hamster ovary cells.A chimeric HS4 insulator-scaffold attachment region enhances transgene expression in transfected Chinese hamster ovary cells.Optimized Selection Marker and CHO Host Cell Combinations for Generating High Monoclonal Antibody Producing Cell Lines.Comprehensive characterization of glutamine synthetase-mediated selection for the establishment of recombinant CHO cells producing monoclonal antibodies.
P2860
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P2860
Early prediction of instability of Chinese hamster ovary cell lines expressing recombinant antibodies and antibody-fusion proteins.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
Early prediction of instabilit ...... and antibody-fusion proteins.
@en
Early prediction of instabilit ...... and antibody-fusion proteins.
@nl
type
label
Early prediction of instabilit ...... and antibody-fusion proteins.
@en
Early prediction of instabilit ...... and antibody-fusion proteins.
@nl
prefLabel
Early prediction of instabilit ...... and antibody-fusion proteins.
@en
Early prediction of instabilit ...... and antibody-fusion proteins.
@nl
P2093
P2860
P356
P1476
Early prediction of instabilit ...... and antibody-fusion proteins.
@en
P2093
Cherylann Kinney
Dawn Ellis
Gordon Moore
Haimanti Dorai
Matt Chomo
Michael J Betenbaugh
Pam Hawley-Nelson
Subinay Ganguly
Susanne Corisdeo
P2860
P304
P356
10.1002/BIT.24367
P577
2011-12-01T00:00:00Z