Cytomegalovirus IE2 protein stimulates interleukin 1beta gene transcription via tethering to Spi-1/PU.1.
about
Covalent modification of the transactivator protein IE2-p86 of human cytomegalovirus by conjugation to the ubiquitin-homologous proteins SUMO-1 and hSMT3b.Evaluation of interactions of human cytomegalovirus immediate-early IE2 regulatory protein with small ubiquitin-like modifiers and their conjugation enzyme Ubc9Regulation of Ets function by protein - protein interactions.Role of noncovalent SUMO binding by the human cytomegalovirus IE2 transactivator in lytic growth.Distinct mechanisms for induction and tolerance regulate the immediate early genes encoding interleukin 1β and tumor necrosis factor α.Activation of interleukin 1beta gene transcription by human cytomegalovirus: molecular mechanisms and relevance to periodontitis.Adipocyte expression of PU.1 transcription factor causes insulin resistance through upregulation of inflammatory cytokine gene expression and ROS production.Inhibition of IL-1beta transcription by peptides derived from the hCMV IE2 transactivator.Biology and pathogenesis of cytomegalovirus in periodontal disease.Viable human cytomegalovirus recombinant virus with an internal deletion of the IE2 86 gene affects late stages of viral replicationNovel immediate-early protein IE19 of human cytomegalovirus activates the origin recognition complex I promoter in a cooperative manner with IE72.Human cytomegalovirus IE2 86 and IE2 40 proteins differentially regulate UL84 protein expression posttranscriptionally in the absence of other viral gene products.Development of cell lines that provide tightly controlled temporal translation of the human cytomegalovirus IE2 proteins for complementation and functional analyses of growth-impaired and nonviable IE2 mutant viruses.Human cytomegalovirus DNA replication requires transcriptional activation via an IE2- and UL84-responsive bidirectional promoter element within oriLyt.Small internal deletions in the human cytomegalovirus IE2 gene result in nonviable recombinant viruses with differential defects in viral gene expression.Human cytomegalovirus IE2 protein interacts with transcription activating factors.Conserved ETS domain arginines mediate DNA binding, nuclear localization, and a novel mode of bZIP interaction.NF-IL6 (C/EBPbeta ) vigorously activates il1b gene expression via a Spi-1 (PU.1) protein-protein tether.
P2860
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P2860
Cytomegalovirus IE2 protein stimulates interleukin 1beta gene transcription via tethering to Spi-1/PU.1.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Cytomegalovirus IE2 protein st ...... n via tethering to Spi-1/PU.1.
@en
Cytomegalovirus IE2 protein st ...... n via tethering to Spi-1/PU.1.
@nl
type
label
Cytomegalovirus IE2 protein st ...... n via tethering to Spi-1/PU.1.
@en
Cytomegalovirus IE2 protein st ...... n via tethering to Spi-1/PU.1.
@nl
prefLabel
Cytomegalovirus IE2 protein st ...... n via tethering to Spi-1/PU.1.
@en
Cytomegalovirus IE2 protein st ...... n via tethering to Spi-1/PU.1.
@nl
P2093
P2860
P356
P1476
Cytomegalovirus IE2 protein st ...... n via tethering to Spi-1/PU.1.
@en
P2093
N Wara-aswapati
S Tetradis
W R Waterman
P2860
P304
P356
10.1128/MCB.19.10.6803
P407
P577
1999-10-01T00:00:00Z