Control of cyclin-dependent kinase inhibitor p27 expression by cap-independent translation.
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The major transcription initiation site of the p27Kip1 gene is conserved in human and mouse and produces a long 5'-UTRExpression of constitutively active 4EBP-1 enhances p27Kip1 expression and inhibits proliferation of MCF7 breast cancer cellsRegulation of expression by promoters versus internal ribosome entry site in the 5'-untranslated sequence of the human cyclin-dependent kinase inhibitor p27kip1p21WAF1 expression induced by MEK/ERK pathway activation or inhibition correlates with growth arrest, myogenic differentiation and onco-phenotype reversal in rhabdomyosarcoma cells.Cap-Independent Translational Control of CarcinogenesisSearching for IRESp27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysisGalectin-4 is involved in p27-mediated activation of the myelin basic protein promoter.Stat1 phosphorylation determines Ras oncogenicity by regulating p27 kip1PRMT5 regulates IRES-dependent translation via methylation of hnRNP A1.Upstream molecular signaling pathways of p27(Kip1) expression: effects of 4-hydroxytamoxifen, dexamethasone, and retinoic acids.Irresistible IRES. Attracting the translation machinery to internal ribosome entry sitesBegin at the beginning: predicting genes with 5' UTRs.Role of BCR-ABL-Y177-mediated p27kip1 phosphorylation and cytoplasmic localization in enhanced proliferation of chronic myeloid leukemia progenitors.Loss of function of the tumor suppressor DKC1 perturbs p27 translation control and contributes to pituitary tumorigenesis.Paradigms of growth control: relation to Cdk activation.The impact of CDK inhibition in human malignancies associated with pronounced defects in apoptosis: advantages of multi-targeting small molecules.The expression of the thyroid-stimulating hormone (TSH) receptor and the cAMP-dependent protein kinase RII beta regulatory subunit confers TSH-cAMP-dependent growth to mouse fibroblasts.The internal ribosome entry site-mediated translation of antiapoptotic protein XIAP is modulated by the heterogeneous nuclear ribonucleoproteins C1 and C2.A novel mutation in the upstream open reading frame of the CDKN1B gene causes a MEN4 phenotype.Heterogeneous nuclear ribonucleoprotein C modulates translation of c-myc mRNA in a cell cycle phase-dependent manner."Nutritional and chemopreventive anti-cancer agents up-regulate expression of p27Kip1, a cyclin-dependent kinase inhibitor, in mouse JB6 epidermal and human MCF7, MDA-MB-321 and AU565 breast cancer cells".Far upstream element binding protein 1 activates translation of p27Kip1 mRNA through its internal ribosomal entry siteTargeting synthetic lethal interactions between Myc and the eIF4F complex impedes tumorigenesisCap-independent translation through the p27 5'-UTR.High levels of Hdmx promote cell growth in a subset of uveal melanomas.Regulation of vascular smooth muscle proliferation by heparin: inhibition of cyclin-dependent kinase 2 activity by p27(kip1).Translate to divide: control of the cell cycle by protein synthesis.Oncogenic AKTivation of translation as a therapeutic target.p27 and leukemia: cell cycle and beyond.Upstream molecular signaling pathways of p27(Kip1) expression in human breast cancer cells in vitro: differential effects of 4-hydroxytamoxifen and deficiency of either D-(+)-glucose or L-leucineLet-7d miRNA Shows Both Antioncogenic and Oncogenic Functions in Osteosarcoma-Derived 3AB-OS Cancer Stem Cells.Cell cycle RNA regulons coordinating early lymphocyte development.ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5'UTR.Role of metalloprotease disintegrin ADAM12 in determination of quiescent reserve cells during myogenic differentiation in vitro.A search for structurally similar cellular internal ribosome entry sites.Phosphorylation-independent stabilization of p27kip1 by the phosphoinositide 3-kinase pathway in glioblastoma cells.AKT activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression.Vitamin D inhibits G1 to S progression in LNCaP prostate cancer cells through p27Kip1 stabilization and Cdk2 mislocalization to the cytoplasm.Polypyrimidine tract-binding protein enhances the internal ribosomal entry site-dependent translation of p27Kip1 mRNA and modulates transition from G1 to S phase.
P2860
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P2860
Control of cyclin-dependent kinase inhibitor p27 expression by cap-independent translation.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Control of cyclin-dependent ki ...... y cap-independent translation.
@en
Control of cyclin-dependent ki ...... y cap-independent translation.
@nl
type
label
Control of cyclin-dependent ki ...... y cap-independent translation.
@en
Control of cyclin-dependent ki ...... y cap-independent translation.
@nl
prefLabel
Control of cyclin-dependent ki ...... y cap-independent translation.
@en
Control of cyclin-dependent ki ...... y cap-independent translation.
@nl
P2093
P2860
P1476
Control of cyclin-dependent ki ...... y cap-independent translation.
@en
P2093
M Hawkinson
R Miskimins
W K Miskimins
P2860
P304
P356
10.1128/MCB.21.15.4960-4967.2001
P407
P577
2001-08-01T00:00:00Z