The C-terminal region of lymphocytic choriomeningitis virus nucleoprotein contains distinct and segregable functional domains involved in NP-Z interaction and counteraction of the type I interferon response.
about
Uncovering viral protein-protein interactions and their role in arenavirus life cycleIdentification, characterization, and in vitro culture of highly divergent arenaviruses from boa constrictors and annulated tree boas: candidate etiological agents for snake inclusion body diseaseReporter-Expressing, Replicating-Competent Recombinant ArenavirusesJunín virus pathogenesis and virus replicationStructure of the LCMV nucleoprotein provides a template for understanding arenavirus replication and immunosuppressionInfluenza A and B virus intertypic reassortment through compatible viral packaging signals.Differential contributions of tacaribe arenavirus nucleoprotein N-terminal and C-terminal residues to nucleocapsid functional activity.Molecular mechanism of arenavirus assembly and budding.Multifunctional nature of the arenavirus RING finger protein Z.Arenavirus variations due to host-specific adaptation.Development of live-attenuated arenavirus vaccines based on codon deoptimizationSelf-association of lymphocytic choriomeningitis virus nucleoprotein is mediated by its N-terminal region and is not required for its anti-interferon functionD471G mutation in LCMV-NP affects its ability to self-associate and results in a dominant negative effect in viral RNA synthesisCleavage of the Junin virus nucleoprotein serves a decoy function to inhibit the induction of apoptosis during infection.Reverse Genetics Approaches to Control Arenavirus.Development of live-attenuated arenavirus vaccines based on codon deoptimization of the viral glycoprotein.Current drug discovery strategies against arenavirus infections.Targeting virulence mechanisms for the prevention and therapy of arenaviral hemorrhagic fever.Human hemorrhagic Fever causing arenaviruses: molecular mechanisms contributing to virus virulence and disease pathogenesis.Novel drug discovery approaches for treating arenavirus infections.Inhibition of arenavirus by A3, a pyrimidine biosynthesis inhibitor.The role of oligomerization for the biological functions of the arenavirus nucleoprotein.Arenavirus nucleoprotein targets interferon regulatory factor-activating kinase IKKε.Lassa Virus Reverse Genetics.Arenavirus Genome Rearrangement for the Development of Live Attenuated Vaccines.Development of Recombinant Arenavirus-Based Vaccines.Arenavirus nucleoproteins prevent activation of nuclear factor kappa B.The use of novel epitope-tagged arenaviruses reveals that Rab5c-positive endosomal membranes are targeted by the LCMV matrix protein.Interactome analysis of the lymphocytic choriomeningitis virus nucleoprotein in infected cells reveals ATPase Na+/K+ transporting subunit Alpha 1 and prohibitin as host-cell factors involved in the life cycle of mammarenaviruses.A Highly Conserved Leucine In Mammarenavirus Matrix Z Protein Is Required For Z Interaction With The Virus L Polymerase And Z Stability In Cells Harboring An Active Viral Ribonucleoprotein.
P2860
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P2860
The C-terminal region of lymphocytic choriomeningitis virus nucleoprotein contains distinct and segregable functional domains involved in NP-Z interaction and counteraction of the type I interferon response.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
The C-terminal region of lymph ...... he type I interferon response.
@en
The C-terminal region of lymph ...... he type I interferon response.
@nl
type
label
The C-terminal region of lymph ...... he type I interferon response.
@en
The C-terminal region of lymph ...... he type I interferon response.
@nl
prefLabel
The C-terminal region of lymph ...... he type I interferon response.
@en
The C-terminal region of lymph ...... he type I interferon response.
@nl
P2093
P2860
P356
P1433
P1476
The C-terminal region of lymph ...... he type I interferon response.
@en
P2093
Benson Yee Hin Cheng
Emilio Ortiz-Riaño
Juan Carlos de la Torre
P2860
P304
13038-13048
P356
10.1128/JVI.05834-11
P407
P577
2011-10-05T00:00:00Z