Regulation of EGFR protein stability by the HECT-type ubiquitin ligase SMURF2. - Wikidata - wikimedia - TriplyDB

Regulation of EGFR protein stability by the HECT-type ubiquitin ligase SMURF2.

Regulation of EGFR protein stability by the HECT-type ubiquitin ligase SMURF2.

http://www.wikidata.org/entity/Q39507845

about

Inducing Oncoprotein Degradation to Improve Targeted Cancer Therapy A new tumour suppression mechanism by p27Kip1: EGFR down-regulation mediated by JNK/c-Jun pathway inhibition.Tristetraprolin mediates radiation-induced TNF-α production in lung macrophages.Effect of erlotinib on epidermal growth factor receptor and downstream signaling in oral cavity squamous cell carcinoma.Disclosure of erlotinib as a multikinase inhibitor in pancreatic ductal adenocarcinoma.The interconnectedness of cancer cell signaling.Oncogenic KRAS impairs EGFR antibodies' efficiency by C/EBPβ-dependent suppression of EGFR expression Wild-type EGFR is stabilized by direct interaction with HSP90 in cancer cells and tumors.Endocytosis of receptor tyrosine kinases Cancer subclonal genetic architecture as a key to personalized medicine.Downregulation of Smurf2, a tumor-suppressive ubiquitin ligase, in triple-negative breast cancers: involvement of the RB-microRNA axis.Efficacy of an EGFR-specific peptide against EGFR-dependent cancer cell lines and tumor xenografts.KRAS protein stability is regulated through SMURF2: UBCH5 complex-mediated β-TrCP1 degradation.Differential protein stability of EGFR mutants determines responsiveness to tyrosine kinase inhibitors.SMURF and NEDD4: sharp shooters monitor the gate keepers and ion traffic controllers of lead astray cell.Prediction of novel genes associated with negative regulators of toll-like receptors-induced inflammation based on endotoxin tolerance.Overcoming intratumor heterogeneity of polygenic cancer drug resistance with improved biomarker integration Regulation of CNKSR2 protein stability by the HECT E3 ubiquitin ligase Smurf2, and its role in breast cancer progression.Smurfs in Protein Homeostasis, Signaling, and Cancer

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P2860

Regulation of EGFR protein stability by the HECT-type ubiquitin ligase SMURF2.

http://www.wikidata.org/entity/Q39507845

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

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2011年論文

@zh-tw

2011年论文

@wuu

2011年论文

@zh

2011年论文

@zh-cn

name

Regulation of EGFR protein stability by the HECT-type ubiquitin ligase SMURF2.

@en

Regulation of EGFR protein stability by the HECT-type ubiquitin ligase SMURF2.

@nl

type

label

Regulation of EGFR protein stability by the HECT-type ubiquitin ligase SMURF2.

@en

Regulation of EGFR protein stability by the HECT-type ubiquitin ligase SMURF2.

@nl

prefLabel

Regulation of EGFR protein stability by the HECT-type ubiquitin ligase SMURF2.

@en

Regulation of EGFR protein stability by the HECT-type ubiquitin ligase SMURF2.

@nl

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P1476

Regulation of EGFR protein stability by the HECT-type ubiquitin ligase SMURF2.

@en

P2093

Aarif Ahsan

http://www.w3.org/2001/XMLSchema#string

Abigail Helman

http://www.w3.org/2001/XMLSchema#string

Ashok Hegde

http://www.w3.org/2001/XMLSchema#string

David G Beer

http://www.w3.org/2001/XMLSchema#string

Dipankar Ray

http://www.w3.org/2001/XMLSchema#string

Guoan Chen

http://www.w3.org/2001/XMLSchema#string

Hiroaki Kiyokawa

http://www.w3.org/2001/XMLSchema#string

Lili Zhao

http://www.w3.org/2001/XMLSchema#string

Mukesh K Nyati

http://www.w3.org/2001/XMLSchema#string

Susmita Ramanand Gurjar

http://www.w3.org/2001/XMLSchema#string

P2860

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

Survival of cancer cells is maintained by EGFR independent of its kinase activity

Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain

The cell cycle-regulatory CDC25A phosphatase inhibits apoptosis signal-regulating kinase 1

AMSH is an endosome-associated ubiquitin isopeptidase

Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain

Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage

Receptor tyrosine kinase signalling as a target for cancer intervention strategies

Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain

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570-578

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scholarly article

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10.1593/NEO.11632

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7

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13

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2011-07-01T00:00:00Z

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21750651

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3132843

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