A Phase 1 Study of the PARP Inhibitor Veliparib in Combination with Temozolomide in Acute Myeloid Leukemia.
about
Pharmacodynamic endpoints as clinical trial objectives to answer important questions in oncology drug development.Excessive Reactive Oxygen Species and Exotic DNA Lesions as an Exploitable LiabilityOpportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases.Genomic instability is a principle pathologic feature of FLT3 ITD kinase activity in acute myeloid leukemia leading to clonal evolution and disease progression.Randomized phase II trial of cytosine arabinoside with and without the CHK1 inhibitor MK-8776 in relapsed and refractory acute myeloid leukemia.Systematic Quantification of Population Cell Death Kinetics in Mammalian Cells.Combination of a hypomethylating agent and inhibitors of PARP and HDAC traps PARP1 and DNMT1 to chromatin, acetylates DNA repair proteins, down-regulates NuRD and induces apoptosis in human leukemia and lymphoma cells.A phase 1 trial evaluating thioridazine in combination with cytarabine in patients with acute myeloid leukemiaMolecular pathophysiology of the myelodysplastic syndromes: insights for targeted therapy
P2860
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P2860
A Phase 1 Study of the PARP Inhibitor Veliparib in Combination with Temozolomide in Acute Myeloid Leukemia.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
A Phase 1 Study of the PARP In ...... ide in Acute Myeloid Leukemia.
@en
A Phase 1 Study of the PARP In ...... ide in Acute Myeloid Leukemia.
@nl
type
label
A Phase 1 Study of the PARP In ...... ide in Acute Myeloid Leukemia.
@en
A Phase 1 Study of the PARP In ...... ide in Acute Myeloid Leukemia.
@nl
prefLabel
A Phase 1 Study of the PARP In ...... ide in Acute Myeloid Leukemia.
@en
A Phase 1 Study of the PARP In ...... ide in Acute Myeloid Leukemia.
@nl
P2093
P2860
P1476
A Phase 1 Study of the PARP In ...... ide in Acute Myeloid Leukemia.
@en
P2093
Alice Chen
Amanda L Blackford
Amy E Dezern
B Douglas Smith
Douglas E Gladstone
Hetty E Carraway
Ismail Ali-Walbi
Ivana Gojo
James G Herman
Jan H Beumer
P2860
P304
P356
10.1158/1078-0432.CCR-16-0984
P407
P577
2016-08-08T00:00:00Z